A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Facile and selectiveGreen chemistry : an international journal and green chemistry resource : GC · 2022
   Article
2. Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens.Frontiers in microbiology · 2021
   Article
3. Development of 6'-Biomolecules · 2020
   Article
4. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Chemical Society reviews · 2018
   Review
5. A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions.ACS chemical biology · 2014
   Article
6. Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.Bioorganic & medicinal chemistry · 2013
   Article
7. Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.Future medicinal chemistry · 2013
   Review
8. Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2012
   Article
9. Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray.Methods in molecular biology (Clifton, N.J.) · 2012
   Article

Corrections and comments

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Authors and funding

4 authors.

Funding

Abstract

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