ArticleDigestive diseases and sciences2011
Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Guideline
- Current management of chronic mesenteric ischemia: A comprehensive review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Immature granulocyte: an early predictor of strangulated adhesive small bowel obstruction.BMC gastroenterology · 2025Article
- Review Article: Mesenteric Ischemia.Current gastroenterology reports · 2020Review
- Clinical management of chronic mesenteric ischemia.United European gastroenterology journal · 2019Review
- On-demand quantitative SERS bioassays facilitated by surface-tethered ratiometric probes.Chemical science · 2018Article
- Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension.Surgical endoscopy · 2018Article
- Article
- Accuracy of the serum intestinal fatty-acid-binding protein for diagnosis of acute intestinal ischemia: a meta-analysis.Scientific reports · 2016Article
- Mechanical Intestinal Obstruction in a Porcine Model: Effects of Intra-Abdominal Hypertension. A Preliminary Study.PloS one · 2016Article
- The Combination of D-Dimer and Peritoneal Irritation Signs as a Potential Indicator to Exclude the Diagnosis of Intestinal Necrosis.Medicine · 2015Article
- Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia.Virchows Archiv : an international journal of pathology · 2015Observational
- [The role of biomarkers in the diagnostics of acute mesenteric ischemia].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Article
- Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia.Cell biochemistry and biophysics · 2013Article
- Temporal relationship of serum markers and tissue damage during acute intestinal ischemia/reperfusion.Clinics (Sao Paulo, Brazil) · 2013Article
- Challenges in diagnosing adhesive small bowel obstruction.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiagnosing chronic gastrointestinal ischemia (CGI) is a challenging problem in clinical practice. Serum markers for CGI would be of great diagnostic value as a non-invasive test method.
aimsThis study investigated serum markers in patients with well-defined ischemia. Furthermore, intestinal mucosal injury was also evaluated in CGI patients.
methodsConsecutive patients suspected of CGI were prospectively enrolled and underwent a diagnostic work-up consisting of gastrointestinal tonometry and either CT or MR angiography. Blood samples for analysis of intestinal fatty acid-binding protein (I-FABP), D-dimer, lactate dehydrogenase (LDH), leucocyte counts, C-reactive protein (CRP), and L-lactate were drawn before and after a standard meal. Intestinal mucosal injury was assessed with glutamine, citrulline and arginine in blood samples and compared to a sugar absorption test (SAT). Test reproducibility was validated in healthy subjects.
resultsForty patients and nine healthy subjects were included. Ischemia was diagnosed in 32 patients (80%). I-FABP, leucocyte counts, LDH, CRP, glutamine, citrulline, arginine and SAT levels did not differ between patients with and without ischemia. L-lactate concentration showed a significant elevation in ischemia patients as compared to non-ischemia patients. In ischemia patients, D-dimer levels showed a significant elevation postprandially as compared to D-dimer levels at baseline. However, these ischemia patients did not show intestinal mucosal injury.
conclusionsI-FABP, leucocyte counts, LDH and CRP levels are not clinically useful for the diagnosis of CGI. However, postprandial rises in L-lactate and D-dimer serum levels can serve as non-invasive indicators of CGI.
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