ArticleProceedings of the National Academy of Sciences of the United States of America1991
Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 113 citations in OpenAlex.
- Auxotrophy-based curation improves the consensus genome-scale metabolic model of yeast.Synthetic and systems biotechnology · 2024Article
- The impact of genomic variation on protein phosphorylation states and regulatory networks.Molecular systems biology · 2022Article
- Spermidine Is Critical for Growth, Development, Environmental Adaptation, and Virulence inFrontiers in microbiology · 2021Article
- Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research.The Journal of biological chemistry · 2018Review
- Fission Yeast srm1 is Involved in Stress Response and Cell Cycle.Current microbiology · 2017Article
- Close encounters with DNA.Journal of physics. Condensed matter : an Institute of Physics journal · 2014Review
- Review
- Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry.Journal of chromatography. A · 2014Article
- Legionella pneumophila requires polyamines for optimal intracellular growth.Journal of bacteriology · 2011Article
- Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.PloS one · 2011Article
- Regulation of the nitrogen transfer pathway in the arbuscular mycorrhizal symbiosis: gene characterization and the coordination of expression with nitrogen flux.Plant physiology · 2010Article
- Review
- Induction of autophagy by spermidine promotes longevity.Nature cell biology · 2009Article
- Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant.Yeast (Chichester, England) · 2009Article
- Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Polyamine analogues: potent inducers of nucleosomal array oligomerization and inhibitors of yeast cell growth.The Biochemical journal · 2007Article
- NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine.Journal of bacteriology · 2005Article
- Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.The Biochemical journal · 2003Article
- Polyamines protect Escherichia coli cells from the toxic effect of oxygen.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A null mutation in the SPE2 gene of Saccharomyces cerevisiae, encoding S-adenosylmethionine decarboxylase, results in cells with no detectable S-adenosylmethionine decarboxylase, spermidine, and spermine. This mutant has an absolute requirement for spermidine or spermine for growth; this requirement is not satisfied by putrescine. Polyamine-depleted cells show a number of microscopic abnormalities that are similar to those reported for several cell division cycle (cdc) and actin mutants. These include a striking increase in cell size, a marked decrease in budding, accumulation of vesicle-like bodies, absence of specific localization of chitin-like material, and abnormal distribution of actin-like material. The absolute requirement for polyamines for growth and the microscopic abnormalities are not seen if the cultures are grown under anaerobic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.