ArticlePLoS computational biology2010
Large-scale analysis of network bistability for human cancers.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals.Molecular biology and evolution · 2022Article
- A general hypothesis of multistable systems in pathophysiology.F1000Research · 2022Article
- Mechanism of Phellodendron and Anemarrhena Drug Pair on the Treatment of Liver Cancer Based on Network Pharmacology and Bioinformatics.Frontiers in oncology · 2022Article
- Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.eLife · 2021Article
- Exact Probability Landscapes of Stochastic Phenotype Switching in Feed-Forward Loops: Phase Diagrams of Multimodality.Frontiers in genetics · 2021Article
- Article
- Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability to Metabolic Homeostasis and Disease states.Scientific reports · 2019Article
- Nanosized functional miRNA liposomes and application in the treatment of TNBC by silencing Slug gene.International journal of nanomedicine · 2019Article
- 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.Mechanisms of ageing and development · 2018Article
- Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling.PLoS computational biology · 2017Article
- Construction of protein interaction network involved in lung adenocarcinomas using a novel algorithm.Oncology letters · 2016Article
- Cancer network activity associated with therapeutic response and synergism.Genome medicine · 2016Article
- Essential functional modules for pathogenic and defensive mechanisms in Candida albicans infections.BioMed research international · 2014Article
- Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype.Wiley interdisciplinary reviews. Membrane transport and signaling · 2014Article
- Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions.PloS one · 2014Article
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- Learning contextual gene set interaction networks of cancer with condition specificity.BMC genomics · 2013Article
- The underappreciated role of allostery in the cellular network.Annual review of biophysics · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human cancers can identify genes that can potentially serve as drug targets or diagnosis biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.