ArticleBritish journal of cancer2010
Identification of thymidylate synthase as a potential therapeutic target for lung cancer.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Does histology predict survival of advanced non-small cell lung cancer patients treated with platin-based chemotherapy? An analysis of the Eastern Cooperative Oncology Group Study E1594.Lung cancer (Amsterdam, Netherlands) · 2013Trial
- Material basis revelation of anti-hepatoma effect of Huachansu (Cinobufacini) through down-regulation of thymidylate synthase.Chinese herbal medicines · 2025Article
- Genome-scale CRISPR-Cas9 screen identifiesMedComm · 2024Article
- Discovery of 5'-Substituted 5-Fluoro-2'-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors.ACS pharmacology & translational science · 2023Article
- Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer.Antioxidants (Basel, Switzerland) · 2022Article
- The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.Theranostics · 2020Article
- Identification of key genes and evaluation of clinical outcomes in lung squamous cell carcinoma using integrated bioinformatics analysis.Oncology letters · 2019Article
- Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.Cell death & disease · 2019Article
- Cross-Correlative Single-Cell Analysis Reveals Biological Mechanisms of Nanoparticle Radiosensitization.ACS nano · 2019Article
- Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.Oncotarget · 2017Article
- Predictive value of thymidylate synthase for the prognosis and survival of lung adenocarcinoma patients.Oncology letters · 2015Article
- Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks.Cell cycle (Georgetown, Tex.) · 2013Article
- Serine, glycine and one-carbon units: cancer metabolism in full circle.Nature reviews. Cancer · 2013Review
- Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2012Article
- Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.British journal of cancer · 2011Article
- A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation.BMC cancer · 2011Article
Corrections and comments
- Retraction · 2025-09-19Concerns/Issues about Data · Concerns/Issues about Image · Duplication of/in Image · Euphemisms for Duplication · Investigation by Journal/Publisher · Investigation by Third Party · Unreliable Data · · See also: https://pubpeer.com/publications/7DDF4339DBB7C79F2A3BB7B53F008E; I Okamoto aka Isamu Okamoto (from cv); K Takezawa aka Ken Takezawa, S Tsukioka aka Sayaka Tsukioka, J Uchida aka Junji Uchida, M Kiniwa aka Mamoru Kiniwa, M Fukuoka aka Masahiro Fukuoka, and K Nakagawa aka Kazuhiko Nakagawa (from related article in same timme frame and coauthors;
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Although inhibition of TS has an antiproliferative effect in cancer cells, the precise mechanism of this effect has remained unclear.
methodsWe examined the effects of TS inhibition with an RNA interference-based approach. The effect of TS depletion on the growth of lung cancer cells was examined using colorimetric assay and flow cytometry.
resultsMeasurement of the enzymatic activity of TS in 30 human lung cancer cell lines revealed that such activity differs among tumour histotypes. Almost complete elimination of TS activity by RNA interference resulted in inhibition of cell proliferation in all tested cell lines, suggestive of a pivotal role for TS in cell proliferation independent of the original level of enzyme activity. The antiproliferative effect of TS depletion was accompanied by arrest of cells in S phase of the cell cycle and the induction of caspase-dependent apoptosis as well as by changes in the expression levels of cyclin E and c-Myc. Moreover, TS depletion induced downregulation of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP), and it seemed to activate the mitochondrial pathway of apoptosis.
conclusionOur data provide insight into the biological relevance of TS as well as a basis for clinical development of TS-targeted therapy for lung cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.