Evidence map›Paper›PMID 20628347›Full record

ReviewNature reviews. Genetics2010

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.

James A Goodrich, Robert Tjian

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 193 citations in OpenAlex.

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  10. The late-evolving salmon and trout join the GnRH1 club.Histochemistry and cell biology · 2023
    Article
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  12. Review
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  16. Transcriptional Responses of Copper-Transport-Related GenesInternational journal of molecular sciences · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

James A GoodrichDepartment of Chemistry and Biochemistry, University of Colorado at Boulder, Colorado 80309, USA.
Robert Tjian
Howard Hughes Medical Institute · USUniversity of Colorado Boulder · US

Funding

THE SV40 TUMOR ANTIGENR37CA025417 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI TJIAN, ROBERT TSE NAN · 1987 to 2013
$6.8M
REGULATION OF TRANSCRIPTION AT THE HUMAN IL2 PROMOTERR01GM055235 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI GOODRICH, JAMES · 1998 to 2011
$2.8M
Howard Hughes Medical InstituteNCI NIH HHS R37 CA025417NCI NIH HHS R37 CA25417NIGMS NIH HHS R01 GM055235NIGMS NIH HHS R01 GM55235
6 · The paper itself

Abstract

The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with 'non-prototypical' subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.

Indexed as

Promoter Regions, GeneticTranscriptional ActivationTranscription, GeneticAnimalsCell DifferentiationDNAEmbryonic DevelopmentFemaleGerm CellsHumansMaleRNA Polymerase IITranscription FactorsDNARNA Polymerase IITranscription Factors

Identifiers

PMID20628347
PMCPMC2965628
OpenAlexW1993470489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.