Evidence map›Paper›PMID 20628344›Full record

ReviewNature reviews. Gastroenterology & hepatology2010

A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps.

Seth Sweetser, Glenn L Alexander, Lisa A Boardman

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Challenges and Opportunities in Cronkhite-Canada Syndrome Research: A Bibliometric Analysis Based on the Web of Science Core Collection.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  2. Arrhythmias in Cronkhite-Canada Syndrome.Internal medicine (Tokyo, Japan) · 2025
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  4. Cronkhite-Canada syndrome tends to be accompanied by colorectal cancer: Report of seven cases.JGH open : an open access journal of gastroenterology and hepatology · 2024
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  16. Cronkhite- Canada syndrome; a case report and review of the literature.Gastroenterology and hepatology from bed to bench · 2016
    Article
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  18. Cronkhite-Canada syndrome: review of the literature.Gastroenterology research and practice · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Seth SweetserDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. sweetser.seth@mayo.edu
Glenn L Alexander
Lisa A Boardman
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 72-year-old man was referred for evaluation of dysgeusia, diarrhea and anorexia. 3 months prior he began to experience taste changes, a decline in appetite and 3-7 loose, non-bloody stools per day. Nausea and lower abdominal cramping subsequently developed and he lost 22.68 kg in weight. His past medical history included atrial fibrillation treated with anticoagulation and digoxin. In the past, he had experienced markedly increased levels of triglycerides and was being treated for this condition with a lipid-lowering agent. There was no family history of colorectal neoplasia or IBD. He was a non-smoker and did not drink alcoholic beverages. INVESTIGATIONS: Medical history, physical examination, laboratory evaluation (including 72 h stool collection), upper endoscopy, colonoscopy and histologic analysis of biopsy samples. DIAGNOSIS: Cronkhite-Canada syndrome. MANAGEMENT: Prednisone (40 mg orally once daily, eventually tapered to 10 mg orally once daily), a histamine-2-receptor blocker and oral micronutrient supplementation (iron, vitamins A, E and D and a multivitamin). Removal of all visible polyps from the anal verge to 25 cm endoscopically by snare polypectomy or with hot biopsy forceps, followed by subtotal colectomy with end-to-side ileorectostomy.

Indexed as

AgedAnti-Inflammatory AgentsBiopsyColonColonoscopyHistamine H2 AntagonistsHumansIntestinal PolyposisMalePrednisoneVitaminsAnti-Inflammatory AgentsHistamine H2 AntagonistsPrednisoneVitamins

Identifiers

PMID20628344
OpenAlexW2076872895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.