ArticleThe Journal of clinical investigation2010
Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Persistent asymptomatic eosinophilia after raw seafood exposure with normal IgE: a case report.Frontiers in immunology · 2026Article
- Enhanced Immune Response Against Echinococcus Granulosus Through a CTLA-4/B7 Affinity-Based Vaccine.Vaccines · 2024Article
- CD4Nature communications · 2024Article
- ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4Autophagy · 2024Article
- Whole-Killed Blood-Stage Vaccine: Is It Worthwhile to Further Develop It to Control Malaria?Frontiers in microbiology · 2021Review
- Transcriptome dynamics of CD4Nature immunology · 2020Article
- The immune response to malaria in utero.Immunological reviews · 2020Review
- A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates.Nature communications · 2019Article
- Comprehensive Review of HumanFrontiers in immunology · 2019Review
- A Synthetic Nanoparticle Based Vaccine Approach Targeting MSP4/5 Is Immunogenic and Induces Moderate Protection Against Murine Blood-Stage Malaria.Frontiers in immunology · 2019Article
- Malaria prevention: from immunological concepts to effective vaccines and protective antibodies.Nature immunology · 2018Review
- In utero priming of highly functional effector T cell responses to human malaria.Science translational medicine · 2018Article
- Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking Activity.Scientific reports · 2018Article
- Induction of immunity following vaccination with a chemically attenuated malaria vaccine correlates with persistent antigenic stimulation.Clinical & translational immunology · 2018Article
- A whole parasite transmission-blocking vaccine for malaria: an ignored strategy.Emerging topics in life sciences · 2017Article
- Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.Science immunology · 2017Article
- Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study.Veterinary research · 2016Article
- PD-1 deficiency enhances humoral immunity of malaria infection treatment vaccine.Infection and immunity · 2015Article
- Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.PLoS pathogens · 2015Article
- Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity.Journal of immunology research · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine should elicit long-lasting immune responses against conserved determinants in the parasite population. Most blood-stage vaccines, however, induce protective antibodies against surface antigens, which tend to be polymorphic. Cell-mediated responses, on the other hand, offer the theoretical advantage of targeting internal antigens that are more likely to be conserved. Nonetheless, few of the current blood-stage vaccine candidates are able to harness vigorous T cell immunity. Here, we present what we believe to be a novel blood-stage whole-organism vaccine that, by combining low doses of killed parasite with CpG-oligodeoxynucleotide (CpG-ODN) adjuvant, was able to elicit strong and cross-reactive T cell responses in mice. Our data demonstrate that immunization of mice with 1,000 killed parasites in CpG-ODN engendered durable and cross-strain protection by inducing a vigorous response that was dependent on CD4+ T cells, IFN-gamma, and nitric oxide. If applicable to humans, this approach should facilitate the generation of robust, cross-reactive T cell responses against malaria as well as antigen availability for vaccine manufacture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.