ArticleBlood2010
Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regulatory KIRScience translational medicine · 2025Article
- Microchimerism and pregnancy complications with placental dysfunction.Seminars in immunopathology · 2025Review
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Maternal Immune Activation and Child Brain Development: A Longitudinal Population-Based Multimodal Neuroimaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.Seminars in immunopathology · 2024Review
- Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells.Science (New York, N.Y.) · 2023Article
- Quantification of Female Chimeric Cells in the Tonsils of Male Children and Their Determinants.Cells · 2023Article
- Markers of placental function correlate with prevalence and quantity of nucleated fetal cells in maternal circulation in normotensive term pregnancies.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity.The Journal of clinical investigation · 2022Article
- Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells.International journal of biological sciences · 2022Review
- Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated With Increased Maternal Microchimerism in the Offspring.The Journal of infectious diseases · 2021Article
- Predictors of maternal-origin microchimerism in young women in the Philippines.American journal of physical anthropology · 2021Article
- Fetal microchimerism and implications for maternal health.Obstetric medicine · 2020Review
- Optimization of Chelex 100 resin-based extraction of genomic DNA from dried blood spots.Biology methods & protocols · 2020Article
- Fetal microchimerism by mode of delivery: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2019Article
- Review
- Immunological implications of pregnancy-induced microchimerism.Nature reviews. Immunology · 2017Review
- Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood.The Journal of infectious diseases · 2017Article
- Statistical Methods for Unusual Count Data: Examples From Studies of Microchimerism.American journal of epidemiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Small amounts of genetically foreign cells (microchimerism, Mc) traffic between a mother and fetus during pregnancy. Commonly, these grafts durably persist. For women, multiple naturally acquired Mc grafts can accrue, as they harbor Mc from their own mothers (maternal Mc, MMc) and subsequently acquire fetal Mc (FMc) through pregnancy. The nature of interactions between these naturally acquired grafts may inform, and be informed by, observations in transplantation, including the effect of noninherited maternal HLA antigens (NIMA) and double-unit cord blood transplantation (CBT). We asked whether FMc and MMc are impacted by the addition of new grafts as evaluated by increasing parity. Mc was identified by quantitative PCR for a nonshared polymorphism unique to the Mc source. Despite increasing sources of Mc, FMc did not increase with increasing parity. MMc concentration was significantly lower with increasing parity. The odds ratio for detection of MMc for 2 or more births compared with 1 birth was .11 (95% CI 0.03-0.42, P = .001). These observations suggest that interactions occur among naturally acquired grafts and are of interest in light of recent observations of graft-graft interaction resulting in predominance of 1 unit in double-unit CBT and the correlation of MMc with the NIMA effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.