ArticleBioinformatics (Oxford, England)2010
PriorsEditor: a tool for the creation and use of positional priors in motif discovery.
Article in Bioinformatics (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Statistical modelling of bacterial promoter sequences for regulatory motif discovery with the help of transcriptome data: application toJournal of the Royal Society, Interface · 2020Article
- Motif discovery and transcription factor binding sites before and after the next-generation sequencing era.Briefings in bioinformatics · 2013Article
- MotifLab: a tools and data integration workbench for motif discovery and regulatory sequence analysis.BMC bioinformatics · 2013Article
- i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules.Nucleic acids research · 2012Article
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Authors and funding
2 authors.
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Abstract
summaryComputational methods designed to discover transcription factor binding sites in DNA sequences often have a tendency to make a lot of false predictions. One way to improve accuracy in motif discovery is to rely on positional priors to focus the search to parts of a sequence that are considered more likely to contain functional binding sites. We present here a program called PriorsEditor that can be used to create such positional priors tracks based on a combination of several features, including phylogenetic conservation, nucleosome occupancy, histone modifications, physical properties of the DNA helix and many more. AVAILABILITY: PriorsEditor is available as a web start application and downloadable archive from http://tare.medisin.ntnu.no/priorseditor (requires Java 1.6). The web site also provides tutorials, screenshots and example protocol scripts.
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