ArticleThe Journal of biological chemistry2010
Ribosome modulation factor, an important protein for cell viability encoded by the polyamine modulon.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Absence of Ribosome Modulation Factor Alters Growth and Competitive Fitness of Escherichia coli.Microbiology spectrum · 2022Article
- Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis.Metabolites · 2022Review
- Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon.International journal of molecular sciences · 2020Article
- Vesicles FromFrontiers in microbiology · 2019Article
- Coordinated Regulation of Rsd and RMF for Simultaneous Hibernation of Transcription Apparatus and Translation Machinery in Stationary-PhaseFrontiers in genetics · 2019Review
- Thermal and Nutritional Regulation of Ribosome Hibernation in Staphylococcus aureus.Journal of bacteriology · 2018Article
- Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management.Current genetics · 2018Review
- Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides.Antimicrobial agents and chemotherapy · 2015Article
- Article
- Endogenous polyamine function--the RNA perspective.Nucleic acids research · 2014Review
- Homeostasis of glutathione is associated with polyamine-mediated β-lactam susceptibility in Acinetobacter baumannii ATCC 19606.Antimicrobial agents and chemotherapy · 2013Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We searched for proteins whose synthesis is enhanced by polyamines at the stationary phase of cell growth using an Escherichia coli polyamine-requiring mutant in which cell viability is greatly decreased by polyamine deficiency. The synthesis of ribosome modulation factor (RMF) was strongly enhanced by polyamines at the level of translation at the stationary phase of cell growth. In rmf mRNA, a Shine-Dalgarno (SD) sequence is located 11 nucleotides upstream of the initiation codon AUG. When the SD sequence was moved to the more common position 8 nucleotides upstream of the initiation codon, the degree of polyamine stimulation was reduced, although the level of RMF synthesis was markedly increased. Polyamine stimulation of RMF synthesis was found to be caused by a selective structural change of the bulged-out region of the initiation site of rmf mRNA. The decrease in cell viability caused by polyamine deficiency was prevented by the addition of a modified rmf gene whose synthesis is not influenced by polyamines. The results indicate that polyamines enhance cell viability of E. coli at least in part by enhancing RMF synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.