ReviewCurrent opinion in microbiology2010
Interaction of phagocytes with filamentous fungi.
Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 129 citations in OpenAlex.
- DisseminatedBMJ case reports · 2026Article
- Deciphering the role of the Sch9 serine/threonine kinase inFrontiers in fungal biology · 2026Article
- Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung.Communications biology · 2024Article
- Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections.Clinical microbiology reviews · 2024Review
- Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections.Clinical reviews in allergy & immunology · 2024Review
- Macrophages inhibit extracellular hyphal growth ofInfection and immunity · 2024Article
- The flow of anisotropic nanoparticles in solution and in blood.Exploration (Beijing, China) · 2023Review
- Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections.NPJ systems biology and applications · 2023Article
- Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic FungusPathogens (Basel, Switzerland) · 2022Article
- Review
- Neutrophil extracellular traps in fungal infections: A seesaw battle in hosts.Frontiers in immunology · 2022Review
- Characterisation ofJournal of fungi (Basel, Switzerland) · 2021Article
- The Host Immune Response toJournal of fungi (Basel, Switzerland) · 2021Review
- Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal PathogenPathogens (Basel, Switzerland) · 2020Article
- Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens.Frontiers in molecular biosciences · 2020Review
- Hybrid Agent-Based Modeling ofFrontiers in microbiology · 2020Article
- Early Interaction of Alternaria infectoria Conidia with Macrophages.Mycopathologia · 2019Article
- Comparative Assessment of Aspergillosis by Virtual Infection Modeling in Murine and Human Lung.Frontiers in immunology · 2019Article
- Article
- Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia.Journal of pediatric hematology/oncology · 2018Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocytosis of conidia by macrophages and destruction of hyphae by neutrophils are key processes in the defense against infections caused by filamentous fungi. Impairment in phagocytic function leads to increased susceptibility for an infection with Aspergillus species. The fact that a Th1-based immune response to an infection with Aspergillus species results in an improved prognosis for survival underlines the importance of the phagocytic response. Recognition of conidia by macrophages occurs after shedding of the hydrophobic rodlet layer during swelling and germination. Whereas Aspergillus conidia are killed by various immune effector cells, hyphae are in particular targeted and killed by neutrophils. Moreover, both conidia and hyphae are trapped in neutrophil extracellular traps (NETs) that form a containment to localize the infection and to prevent systemic spreading of the fungus in the host. In addition, A. fumigatus interferes with the innate immunity, with both the complement system and defense mechanisms of phagocytes, thereby evading at least in part the innate immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.