ReviewSeminars in immunology2010
Eliciting the T cell fate with Notch.
Review in Seminars in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Ciclopirox reprograms effector responses and modulates Notch1 activation in activated human T cells.iScience · 2026Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- The thymus road to a T cell: migration, selection, and atrophy.Frontiers in immunology · 2024Review
- Stem cell decoupling underlies impaired lymphoid development during aging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Hematopoietic progenitor cell lines with myeloid and lymphoid potential.Nature methods · 2013Article
- Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production.PloS one · 2013Article
- Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.Experimental brain research · 2012Review
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.The Journal of allergy and clinical immunology · 2011Article
- Molecular and cellular basis of T cell lineage commitment: An overview.Seminars in immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Multipotent progenitors arrive at the thymus via the blood. Constraining the non-T cell fates of these progenitors while promoting the T cell fate is a major task of the thymus. Notch appears to be the initial trigger for a developmental program that eventually results in T cell lineage commitment. Several downstream targets of Notch are known, but the specific roles of each are poorly understood. A greater understanding of how Notch and other thymic signals direct progenitors to a T cell fate could be useful for translational work. For example, such work could eventually allow for the generation of fully competent T cells in vitro that could supplement the waning T cell numbers and function in the elderly and boost T cell-mediated immunity in patients with immunodeficiency and after stem cell transplantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.