ArticleJournal of biomechanics2010
Automated image analysis method for quantifying damage accumulation in tendon.
Article in Journal of biomechanics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Rotator Cuff Tear-induced Changes in Tendon Structure and Mechanics Measured by Quantitative Magnetic Resonance Imaging.Annals of biomedical engineering · 2025Article
- Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure.Journal of biomechanics · 2023Article
- Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.Scientific reports · 2018Article
- Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics.Journal of biomechanics · 2018Article
- Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading.Journal of the Royal Society, Interface · 2018Article
- Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells.Biology open · 2016Article
- Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Delayed exercise promotes remodeling in sub-rupture fatigue damaged tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Biomechanical and structural response of healing Achilles tendon to fatigue loading following acute injury.Journal of biomechanics · 2014Article
- Musculoskeletal regeneration and its implications for the treatment of tendinopathy.International journal of experimental pathology · 2013Review
- Structural and mechanical effects of in vivo fatigue damage induction on murine tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
- Quantification of collagen organization using fractal dimensions and Fourier transforms.Acta histochemica · 2012Article
- Tendon fatigue in response to mechanical loading.Journal of musculoskeletal & neuronal interactions · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Tendon pathology is frequently sub-clinical prior to frank rupture, denoting the need for non-destructive methods of assessing disease presence and progression. Despite the lack of clinical presentation, previous studies have observed that distinct changes to the tendon microstructure are present, and that such qualitative changes have a dose-response relationship with the level of damage accumulated. These initial findings suggest that there is value in investigating the physical nature of damage within tendon, not only to better understand the pathological process, but also to gain insight into reparative processes and develop treatments. However, a necessary first step towards carrying out these avenues of research is to develop diagnostic tools for quantitatively assessing the level of damage present. In this study, we established a dose-response relationship between a quantitative measure of structural damage and the level of global damage induced. Furthermore, we developed and validated an automated technique for quantifying matrix disorganization (damage), which correlates and co-localizes strongly with manual quantification. In combination, these findings allow us to measure the amount of damage accumulation of a region of tendon on a clinical scale, rapidly and accurately.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.