ArticleJournal of biomechanics2010
Effect of sulfated glycosaminoglycan digestion on the transverse permeability of medial collateral ligament.
Article in Journal of biomechanics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons.The Journal of physiology · 2025Article
- Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework.British journal of sports medicine · 2023Review
- The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review.Journal of biomechanical engineering · 2022Review
- Proteoglycans play a role in the viscoelastic behaviour of the canine cranial cruciate ligament.Frontiers in bioengineering and biotechnology · 2022Article
- Tensile mechanical changes in the Achilles tendon due to Insertional Achilles tendinopathy.Journal of the mechanical behavior of biomedical materials · 2020Article
- Evaluation of transverse poroelastic mechanics of tendon using osmotic loading and biphasic mixture finite element modeling.Journal of biomechanics · 2020Article
- Load transfer, damage, and failure in ligaments and tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Multiscale Mechanical Evaluation of Human Supraspinatus Tendon Under Shear Loading After Glycosaminoglycan Reduction.Journal of biomechanical engineering · 2017Article
- Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides.Nature communications · 2017Article
- Mechanical changes in the Achilles tendon due to insertional Achilles tendinopathy.Journal of the mechanical behavior of biomedical materials · 2016Article
- Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading.Acta biomaterialia · 2015Article
- Molecular mechanisms of scar-sourced axon growth inhibitors.Brain research · 2015Review
- Osmotic pressure induced tensile forces in tendon collagen.Nature communications · 2015Article
- Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon.Journal of biomechanical engineering · 2012Article
- The regional contribution of glycosaminoglycans to temporomandibular joint disc compressive properties.Journal of biomechanical engineering · 2012Article
- Regional variation in the mechanical role of knee meniscus glycosaminoglycans.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus.Journal of the mechanical behavior of biomedical materials · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dermatan and chondroitin sulfate glycosaminoglycans (GAGs) comprise over 90% of the GAG content in ligament. Studies of their mechanical contribution to soft tissues have reported conflicting results. Measuring the transient compressive response and biphasic material parameters of the tissue may elucidate the contributions of GAGs to the viscoelastic response to deformation. The hypotheses of the current study were that digestion of sulfated GAGs would decrease compressive stress and aggregate modulus while increasing the permeability of porcine medial collateral ligament (MCL). Confined compression stress relaxation experiments were carried out on porcine MCL and tissue treated with chondroitinase ABC (ChABC). Results were fit to a biphasic constitutive model to derive permeability and aggregate modulus. Bovine articular cartilage was used as a benchmark tissue to verify that the apparatus provided reliable results. GAG digestion removed up to 88% of sulfated GAGs from the ligament. Removal of sulfated GAGs increased the permeability of porcine MCL nearly 6-fold versus control tissues. Peak stress decreased significantly. Bovine articular cartilage exhibited the typical reduction of GAG content and resultant decreases in stress and modulus and increases in permeability with ChABC digestion. Given the relatively small amount of GAG in ligament (<1% of tissue dry weight) and the significant change in peak stress and permeability upon removal of GAGs, sulfated GAGs may play a significant role in maintaining the apposition of collagen fibrils in the transverse direction, thus supporting dynamic compressive loads experienced by the ligament during complex joint motion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.