ArticleClinical and molecular allergy : CMA2010
IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring.
Article in Clinical and molecular allergy : CMA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The "Survivor Peptide" Hypothesis: Structural Resilience and Immunological Persistence of Food Allergens in the Gut-Mammary Axis.Nutrients · 2026Review
- Dynamic Changes in Antibodies and Proteome in Breast Milk of Mothers Infected with Wild-Type SARS-CoV-2 and Omicron: A Longitudinal Study.Nutrients · 2025Article
- Preclinical models of maternal asthma and progeny outcomes: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach.Frontiers in cellular and infection microbiology · 2024Review
- Levels of toxic and trace metals in the breast milk of lactating mothers in Abeokuta, Ogun State, Nigeria.Toxicology reports · 2023Article
- Immunomodulatory Effect of Infectious Disease of a Breastfed Child on the Cellular Composition of Breast Milk.Nutrients · 2023Article
- Human IgE does not bind to human FcRn.Scientific reports · 2022Article
- The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021Review
- The Breast Milk Immunoglobulinome.Nutrients · 2021Review
- Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.Frontiers in immunology · 2019Review
- Maternal Antiasthma Simplified Herbal Medicine Intervention therapy prevents airway inflammation and modulates pulmonary innate immune responses in young offspring mice.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Article
- Cadmium, lead, copper and zinc in breast milk in Poland.Biological trace element research · 2014Article
- Maternal allergy is associated with surface-bound IgE on cord blood basophils.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Article
- Antibodies and their receptors: different potential roles in mucosal defense.Frontiers in immunology · 2013Article
- FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Neonatal Fc receptor (FcRn) and maternal-to-newborn IgE absorption.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Mucosal antibodies in the regulation of tolerance and allergy to foods.Seminars in immunopathology · 2012Review
- Maternal peanut consumption provides protection in offspring against peanut sensitization that is further enhanced when co-administered with bacterial mucosal adjuvant.Food research international (Ottawa, Ont.) · 2011Article
- Transmission of murine cytomegalovirus in breast milk: a model of natural infection in neonates.Journal of virology · 2011Article
- Is there a regulatory role of immunoglobulins on tissue forming cells relevant in chronic inflammatory lung diseases?Journal of allergy · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to allergic airway disease transmitted from allergic mothers to breastfed offspring requires maternal B cell-derived factors.
objectiveThe aim of this study was to investigate the role of offspring neonatal Fc receptor for IgG uptake by intestinal epithelial cells (FcRn) in this breast milk transferred protection from allergy.
methodsAllergic airway disease was induced during pregnancy in C57BL/6 female mice. These allergic mothers foster nursed naive FcRn+/- or FcRn-/- progeny born to FcRn+/- females that were mated to C57BL/6J-FcRn-/- male mice. In offspring deficient in FcRn, we expected reduced levels of systemic allergen-specific IgG1, a consequence of decreased absorption of maternal IgG from the lumen of the neonatal gastrointestinal tract. Using this model, we were able to investigate how breast milk IgG affected offspring responses to allergic sensitization.
resultsLevels of maternal antibodies absorbed from the breast milk of allergic foster mothers were determined in weanling FcRn-sufficient or -deficient mice. Maternal transmission of allergen-specific IgG1 to breastfed FcRn-/- offspring was at levels 103-104 lower than observed in FcRn+/- or FcRn+/+ mice. Five weeks after weaning, when offspring were 8 wk old, mice were sensitized and challenged to evaluate their susceptibility to develop allergic airway disease. Protection, indicated by reduced parameters of disease (allergen-specific IgE in serum, eosinophilic inflammation in the airways and lung) were evident in FcRn-sufficient mice nursed as neonates by allergic mothers. In contrast, FcRn-deficient mice breastfed by the same mothers acquired limited, if any, protection from development of allergen-specific IgE and associated pathology.
conclusionsFcRn expression was a major factor in determining how breastfed offspring of allergic mothers acquired levels of systemic allergen-specific IgG1 sufficient to inhibit allergic sensitization in this model.
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Registered trials
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