ArticleCancer science2010
Tobacco smoking and regression of low-grade cervical abnormalities.
Article in Cancer science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03093623 (The Effect of Physical Activity and Abstain From Smoking on the Regression of Precancerous Lesion.), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Physical Activity and Abstain From Smoking on the Regression of Precancerous Lesion.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study.International journal of clinical oncology · 2012Trial
- The Predictive Impact of HPV Genotypes, Tumor Suppressors and Local Immune Response in the Regression of Cervical Intraepithelial Neoplasia 2-3: A Prospective Population-Based Cohort Study.International journal of molecular sciences · 2025Article
- A prospective clinical trial of diathermy ablation for patients with high-grade cervical intraepithelial neoplasia from a single institution in Japan.Scientific reports · 2024Article
- Impact of smoking exposure on human papillomavirus clearance among Chinese women: A follow-up propensity score matching study.Tobacco induced diseases · 2023Article
- Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy.Journal of clinical medicine · 2022Review
- Health-related quality of life in women after colposcopy: results from a longitudinal patient survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Early life exposure to tobacco smoke and ovarian cancer risk in adulthood.International journal of epidemiology · 2021Article
- Sociodemographic and clinical profile of geriatric patients with cervical cancer-An audit from a tertiary cancer center in India.Journal of family medicine and primary care · 2020Article
- Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.Cancer epidemiology · 2020Article
- Article
- Budget impact analysis of cervical cancer screening in Portugal: comparison of cytology and primary HPV screening strategies.BMC public health · 2019Article
- Association Between Passive Smoking and the Risk of Cervical Intraepithelial Neoplasia 1 in Korean Women.Journal of epidemiology · 2018Article
- Tobacco Exposure Enhances Human Papillomavirus 16 Oncogene Expression via EGFR/PI3K/Akt/c-Jun Signaling Pathway in Cervical Cancer Cells.Frontiers in microbiology · 2018Article
- Association between secondhand smoke exposure and abnormal cervical cytology: A one-to-one matched case-control study.Tobacco induced diseases · 2018Article
- Study of 2 years follow-up of referral patients with abnormal Pap smear.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.Carcinogenesis · 2014Article
- Evaluation of HPV infection and smoking status impacts on cell proliferation in epithelial layers of cervical neoplasia.PloS one · 2014Article
- Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study.International journal of clinical oncology · 2013Article
- Association between smoking and size of anal warts in HIV-infected women.International journal of STD & AIDS · 2012Article
- Cigarette smoke stimulates VEGF-C expression in cervical intraepithelial neoplasia (CIN) 1 and 2 lesions.International journal of clinical oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of tobacco smoking in the multistage carcinogenesis at the cervix is not fully understood because of a paucity of prospective data. To assess the relationship between smoking and spontaneous regression of cervical precursor lesions, a total of 516 women with low-grade squamous intraepithelial lesion (LSIL) were monitored by cytology and colposcopy every 4 months. Probability of LSIL regression within 2 years was analyzed in relation to smoking behaviors, with regression defined as at least two consecutive negative Pap smears and normal colposcopy. Women's age, initial biopsy results, and human papillomavirus (HPV) genotypes were included in the multivariate models for adjustments. Our study subjects included 258 never-smokers and 258 smokers (179 current and 79 former smokers). During a mean follow-up time of 39.8 months, 320 lesions regressed to normal cytology. Probability of regression within 2 years was significantly lower in smokers than in never-smokers (55.0%vs 68.8%, P = 0.004). The risk of LSIL persistence increased with smoking intensity and duration and with younger age at starting smoking (P = 0.003, P < 0.001, and P = 0.03, respectively). Smokers had twice as high a risk of persistent HPV infection compared to never-smokers (odds ratio, 2.50; 95% confidence interval, 1.30-4.81; P = 0.006). In young women, passive smoking since childhood reduced probability of regression within 2 years (56.7%vs 85.9%, P < 0.001). Further adjustments for a wide range of cervical cancer risk factors did not change the findings. In conclusion, tobacco smoking may interfere with regression of cervical precursor lesions. Childhood exposure to second-hand smoke may increase a risk of persistent cervical abnormalities among young women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.