ArticleAging cell2010
The migration of mitochondrial DNA fragments to the nucleus affects the chronological aging process of Saccharomyces cerevisiae.
Article in Aging cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Oligomer-based functions of mitochondrial porin.Nature communications · 2025Article
- Article
- Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.PLoS biology · 2024Article
- Mitochondrial genome plasticity of mammalian species.BMC genomics · 2024Article
- Evolutionary trajectory of organelle-derived nuclear DNAs in the Triticum/Aegilops complex species.Plant physiology · 2024Article
- The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome.Biomolecules · 2023Review
- Generation of somaticFrontiers in cell and developmental biology · 2023Article
- Mitochondrial signal transduction.Cell metabolism · 2022Review
- Metabolic, structural, and proteomic changes in Candida albicans cells induced by the protein-carbohydrate fraction of Dendrobaena veneta coelomic fluid.Scientific reports · 2021Article
- Review
- Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage.Molecules (Basel, Switzerland) · 2020Review
- Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.Seminars in cancer biology · 2017Review
- Numtogenesis as a mechanism for development of cancer.Seminars in cancer biology · 2017Review
- Quantifying the Number of Independent Organelle DNA Insertions in Genome Evolution and Human Health.Genome biology and evolution · 2017Article
- Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.Genome medicine · 2017Article
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Mitochondrial maintenance failure in aging and role of sexual dimorphism.Archives of biochemistry and biophysics · 2015Review
- Mechanisms by which different functional states of mitochondria define yeast longevity.International journal of molecular sciences · 2015Review
- Insights from space: potential role of diet in the spatial organization of chromosomes.Nutrients · 2014Review
- Reversible mitochondrial DNA accumulation in nuclei of pluripotent stem cells.Stem cells and development · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Migration of fragmented mitochondrial DNA (mtDNA) to the nucleus has been shown to occur in multiple species including yeast, plants, and mammals. Several human diseases, including Pallister-Hall syndrome and mucolipidosis, can be initiated by mtDNA insertion mutagenesis of nuclear DNA. In yeast, we demonstrated that the rate of mtDNA fragments translocating to the nucleus increases during chronological aging. The yeast chronological lifespan (CLS) is determined by the survival of nondividing cell populations. Whereas yeast strains with elevated migration rates of mtDNA fragments to the nucleus showed accelerated chronological aging, strains with decreased mtDNA transfer rates to the nucleus exhibited an extended CLS. Although one of the most popular theories of aging is the free radical theory, migration of mtDNA fragments to the nucleus may also contribute to the chronological aging process by possibly increasing nuclear genomic instability in cells with advanced age.
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