ArticleNucleic acids research1991
Promoter function and structure of the growth factor-inducible immediate early gene cyr61.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 88 citations in OpenAlex.
- Spatial and Single-Cell Transcriptomics Reveal Keratinocytes as Key Players in Vulvar Lichen Sclerosus Pathogenesis.The Journal of investigative dermatology · 2026Article
- Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo.Advances in experimental medicine and biology · 2022Article
- Article
- Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics.Genes & development · 2017Article
- CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.Canadian journal of physiology and pharmacology · 2017Article
- Serum regulation of Id1 expression by a BMP pathway and BMP responsive element.Biochimica et biophysica acta · 2013Article
- CCN1/CYR61: the very model of a modern matricellular protein.Cellular and molecular life sciences : CMLS · 2011Review
- Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.The Journal of biological chemistry · 2009Article
- Functions and mechanisms of action of CCN matricellular proteins.The international journal of biochemistry & cell biology · 2009Review
- Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- The matricellular protein CCN1 is essential for cardiac development.Circulation research · 2006Article
- Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients.Oncogene · 2005Article
- Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death.Journal of virology · 2004Article
- CYR61 (CCN1) is essential for placental development and vascular integrity.Molecular and cellular biology · 2002Article
- Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c.The Biochemical journal · 2001Article
- 5' flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus.Molecular pathology : MP · 2001Article
- NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues.Molecular pathology : MP · 2001Review
- Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals.Oncogene · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
cyr61 is an immediate early gene that is transcriptionally activated in 3T3 fibroblasts by serum, platelet-derived growth factor, fibroblast growth factor, and the tumor promoter TPA with kinetics similar to the induction of c-fos. cyr61 encodes a secreted protein that is associated with the cell surface and the extracellular matrix, and may play a role in cell-cell communication. We report here the complete nucleotide sequence of the mouse cyr61 gene, which contains four short introns. The transcription start site was mapped by S1 nuclease and primer extension analyses. A 2 kb 5' flanking DNA fragment functions as a serum-inducible promoter. This DNA fragment contains a poly(CA) sequence that can adopt the Z DNA form. In addition, it contains a sequence that resembles the serum response element (SRE) originally identified in the c-fos promoter. We show that deletion of the cry61 SRE-like sequence abrogates serum inducibility. Furthermore, this SRE-like sequence is sufficient to confer serum and growth factor inducibility when linked to a basal promoter, and binds the 67 kD serum response factor in vitro. We conclude that the cyr61 SRE functions as a serum response element and may account for the coordinate activation of cyr61 and c-fos.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.