ArticleNucleic acids research1991
Cooperation between upstream and downstream elements of the adenovirus major late promoter for maximal late phase-specific transcription.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.Nucleic acids research · 2011Article
- The adenovirus L4 33-kilodalton protein binds to intragenic sequences of the major late promoter required for late phase-specific stimulation of transcription.Journal of virology · 2007Article
- Encapsidation of viral DNA requires the adenovirus L1 52/55-kilodalton protein.Journal of virology · 1998Article
- Characterization of bovine adenovirus type 3 early region 2B.Virus genes · 1998Article
- The product of the adenovirus intermediate gene IX is a transcriptional activator.Journal of virology · 1997Article
- Nucleoplasmic and nucleolar distribution of the adenovirus IVa2 gene product.Journal of virology · 1996Article
- Properties of the adenovirus IVa2 gene product, an effector of late-phase-dependent activation of the major late promoter.Journal of virology · 1996Article
- The herpes simplex virus type 1 major capsid protein (VP5-UL19) promoter contains two cis-acting elements influencing late expression.Journal of virology · 1994Article
- The product of the adenovirus intermediate gene IVa2 is a transcriptional activator of the major late promoter.Journal of virology · 1994Article
- Adenovirus DNA replication facilitates binding of the MLTF/USF transcription factor to the viral major late promoter within infected cells.Nucleic acids research · 1992Article
- Identification of a novel downstream binding protein implicated in late-phase-specific activation of the adenovirus major late promotor.Nucleic acids research · 1992Article
- Evidence that USF can interact with only a single general transcription complex at one time.Molecular and cellular biology · 1992Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription from the adenovirus major late promoter (MLP) is greatly stimulated during lytic infection, after replication of the viral DNA has started. This replication-dependent activation has previously been shown to be mediated by a positive regulatory cellular protein(s). Binding of this factor(s) to sequence elements (DE1 and DE2), located between positions +76 and +124, with respect to the MLP transcriptional startsite, is detected only after the onset of DNA replication. Using a cell-free transcription system which mimics the late phase induction of the MLP and DNA binding assays, we now present evidence showing that maximal stimulation also depends on the MLP upstream element (UE), without involving increased DNA binding activity of the corresponding factor (UEF) during the lytic cycle. Our results indicate that the upstream and downstream elements act cooperatively on transcription efficiency, although no direct interactions between the cognate factors could be demonstrated. These observations strongly suggest that the elevated rate of transcription originating at the MLP startsite, late in infection, results from the simultaneous action of factors bound at the upstream and downstream elements onto a common target within the basal transcription machinery.
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