ArticleJournal of clinical laboratory analysis2010
Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.
Article in Journal of clinical laboratory analysis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Expansion of the genetic and phenotypic spectrum of hereditary spastic paraplegia caused byFrontiers in pediatrics · 2025Article
- Delineation of single-cell Altas provides new insights for development of coronary artery lesions in Kawasaki disease: bad and good signaling molecules.Frontiers in pediatrics · 2025Article
- Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12.ACS medicinal chemistry letters · 2023Article
- Genetic variants in BAT2 are associated with immune responsiveness to influenza vaccination.Frontiers in genetics · 2023Article
- Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension.Life science alliance · 2022Article
- Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.Science immunology · 2022Article
- α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases.Journal of medicinal chemistry · 2021Review
- Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes.PloS one · 2020Article
- Insights Into Coronary Artery Lesions in Kawasaki Disease.Frontiers in pediatrics · 2020Review
- Coronary Aneurysm: An Enigma Wrapped in a Mystery.Aorta (Stamford, Conn.) · 2019Article
- Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease.Open biology · 2018Review
- Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.Scientific reports · 2015Article
- Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Kawasaki disease patients homozygous for the rs12252-C variant of interferon-induced transmembrane protein-3 are significantly more likely to develop coronary artery lesions.Molecular genetics & genomic medicine · 2014Article
- BAG-6, a jack of all trades in health and disease.Cellular and molecular life sciences : CMLS · 2014Review
- Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).PloS one · 2014Article
- Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism.Biochimica et biophysica acta · 2013Review
- Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Review
- Can Coronary Artery Involvement in Kawasaki Disease be Predicted?Diagnostics (Basel, Switzerland) · 2013Review
- Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children.PloS one · 2013Article
Corrections and comments
- Erratum issuedWang, Yu-Kuo [added]; Lo, Ming-Min [removed]
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
capsuleHLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations.
objectiveKD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno-inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)-BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA.
methodsIndividuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (-8671, 16483), BAT3 (8854, 2-24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2(-8671)-BAT2(16483)-BAT3(8854)-BAT3(2-24)-BAT5(22655)-BAT5(9569)) in each group were compared.
resultsGenotype distribution and allele frequency of BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 -8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A-related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilities of KD with CAA susceptibility.
conclusionBAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher KD susceptibility and CAA formation. HLA-B region polymorphisms might contribute to the pathogenesis of KD and CAA.
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