Trial reportCancer2010
Complementary therapies for children undergoing stem cell transplantation: report of a multisite trial.
Trial report in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Psychosocial interventions for children and adolescents across the cancer care continuum: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Psychological interventions for needle-related procedural pain and distress in children and adolescents.The Cochrane database of systematic reviews · 2018Pooled it
- A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- How effective are spiritual care and body manipulation therapies in pediatric oncology? A systematic review of the literature.Global journal of health science · 2013Pooled it
- Effects of laughter therapy on quality of life in patients with cancer: An open-label, randomized controlled trial.PloS one · 2019Trial
- Adjustment in parents of children undergoing stem cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014Trial
- Trial
- Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children's Oncology Group.Bone marrow transplantation · 2012Trial
- Resilience in children undergoing stem cell transplantation: results of a complementary intervention trial.Pediatrics · 2012Trial
- The Mechanism by 18 RCTs Psychosocial Interventions Affect the Personality, Emotions, and Behaviours of Paediatric and Young Adult Cancer Patients: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Acupressure and Therapeutic Touch in Childhood Cancer to Promote Subjective and Intersubjective Experiences of Well-being During Curative Treatment.Global advances in health and medicine · 2019Article
- Caregiver Perceptions of Music Therapy for Children Hospitalized for a Blood and Marrow Transplant: An Interpretivist Investigation.Global advances in health and medicine · 2018Article
- Article
- Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Cancer-related stress and complementary and alternative medicine: a review.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Massage for children undergoing hematopoietic cell transplantation: a qualitative report.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundChildren undergoing stem cell transplant (SCT) experience high levels of somatic distress and mood disturbance. This trial evaluated the efficacy of complementary therapies (massage, humor therapy, relaxation/imagery) for reducing distress associated with pediatric SCT.
methodsAcross 4 sites, 178 pediatric patients scheduled to undergo SCT were randomized to a child-targeted intervention involving massage and humor therapy, the identical child intervention plus a parent intervention involving massage and relaxation/imagery, or standard care. Randomization was stratified by site, age, and type of transplant. The interventions began at admission and continued through SCT Week +3. Primary outcomes included patient and parent reports of somatic distress and mood disturbance obtained weekly from admission through Week +6 using the Behavioral, Affective, and Somatic Experiences Scales. Secondary outcomes included length of hospitalization, time to engraftment, and usage of narcotic analgesic and antiemetic medications.
resultsA mixed model approach was used to assess longitudinal trends of patient and parent report outcomes and to test differences between groups on these measures. Significant changes across time were observed on all patient and parent report outcomes. However, no significant differences between treatment arms were found on the primary outcomes. Similarly, no significant between-group differences were noted on any of the medical variables as secondary outcomes.
conclusionsResults of this multisite trial failed to document significant benefits of complementary interventions in the pediatric SCT setting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.