ArticleUrological research2010
Mineralogical signatures of stone formation mechanisms.
Article in Urological research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Colloid assembly and transformation (CAT): The relationship of PILP to biomineralization.Journal of structural biology: X · 2022Article
- Article
- Article
- Microstructures of Randall's plaques and their interfaces with calcium oxalate monohydrate kidney stones reflect underlying mineral precipitation mechanisms.Urolithiasis · 2017Article
- Biomimetic synthesis of struvite with biogenic morphology and implication for pathological biomineralization.Scientific reports · 2015Article
- Biomimetic Randall's plaque as an in vitro model system for studying the role of acidic biopolymers in idiopathic stone formation.Urolithiasis · 2015Article
- Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.Acta biomaterialia · 2014Article
- Association of Randall plaque with collagen fibers and membrane vesicles.The Journal of urology · 2012Article
- Mechanisms of Stone Formation.Clinical reviews in bone and mineral metabolism · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms involved in biomineralization are modulated through interactions with organic matrix. In the case of stone formation, the role of the organic macromolecules in the complex urinary environment is not clear, but the presence of mineralogical 'signatures' suggests that some aspects of stone formation may result from a non-classical crystallization process that is induced by acidic proteins. An amorphous precursor has been detected in many biologically controlled mineralization reactions, which is thought to be regulated by non-specific interactions between soluble acidic proteins and mineral ions. Using in vitro model systems, we find that a liquid-phase amorphous mineral precursor induced by acidic polypeptides can lead to crystal textures that resemble those found in Randall's plaque and kidney stones. This polymer-induced liquid-precursor process leads to agglomerates of coalesced mineral spherules, dense-packed spherulites with concentric laminations, mineral coatings and 'cements', and collagen-associated mineralization. Through the use of in vitro model systems, the mechanisms involved in the formation of these crystallographic features may be resolved, enhancing our understanding of the potential role(s) that proteins play in stone formation.
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