ArticleAnnals of surgical oncology2010
Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III.
Article in Annals of surgical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Tumour deposits are associated with worse survival than extranodal extension; a network meta-analysis on tumour nodules in colorectal cancer.Histopathology · 2025Pooled it
- Prognostic value of tumor deposits for long-term oncologic outcomes in patients with stage III colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Tumour deposits are a significant prognostic factor in gastric cancer - a systematic review and meta-analysis.Histopathology · 2019Pooled it
- Rectal cancer: a methodological approach to matching PET/MRI to histopathology.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Trial
- PET/MRI and PET/CT hybrid imaging of rectal cancer - description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Trial
- Independent prognostic value of tumor deposits in stage III colorectal cancer: a large-scale systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- Prognostic impact of tumor deposits in colorectal cancer.World journal of gastroenterology · 2025Article
- Prognostic impact and independent significance of tumor deposits in early-stage colon cancer: a population-based cohort study.International journal of colorectal disease · 2025Article
- Utilizing tumor deposit count as a stratification criterion in revising TNM staging system for patients with colorectal cancer: a nomogram review study.Frontiers in oncology · 2025Article
- The value analysis of tumor deposit in the comprehensive evaluation before differentiated thyroid cancer RAI therapy.Frontiers in oncology · 2025Article
- Tumor Deposits as an Adverse Prognostic Indicator in Stage III Colon Cancer: A Multicenter Database Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- The Relationship between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma.Journal of clinical medicine · 2024Article
- Tumour deposits are independently associated with recurrence in colon cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer.World journal of gastrointestinal oncology · 2023Article
- Tumor deposits are associated with a higher risk of peritoneal disease in non-metastatic colorectal cancer patients.Journal of surgical oncology · 2023Article
- Risk factors predict microscopic extranodal tumor deposits in advanced stage III colon cancer patients.World journal of gastroenterology · 2023Article
- Readjustment of nodal staging by integrating tumor deposits and positive lymph nodes in patients with stage III colon cancer: a population-based analysis.American journal of cancer research · 2023Article
- High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence.Scientific reports · 2022Article
- Significance of tumor deposits combined with lymph node metastasis in stage III colorectal cancer patients: a retrospective multi-center cohort study from China.International journal of colorectal disease · 2022Article
- The Prognostic Value of Adjuvant Chemotherapy in Colon Cancer With Solitary Tumor Deposit.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic role of pericolic or perirectal isolated tumor deposits (ITDs) in node-negative colorectal cancer (CRC) patients is unclear. Rules to define ITDs as regional lymph node metastases changed in subsequent editions of the TNM staging without substantial evidence. Aim of this study was to investigate the correlation between ITDs and disease recurrence in stage II and III CRC patients. MATERIALS AND
methodsThe medical files of 870 CRC patients were reviewed. Number, size, shape, and location pattern of all ITDs in node-negative patients were examined in relation to involvement of vascular structures and nerves. The correlation between ITDs and the development of recurrent disease was investigated.
resultsDisease recurrence was observed in 50.0% of stage II patients with ITDs (13 of 26), compared with 24.4% of stage II patients without ITDs (66 of 270) (P < .01). Disease-free survival of ITD-positive stage II patients was comparable with that of stage III patients. Also within stage III, more recurrences were observed in ITD-positive patients compared with ITD-negative patients (65.1 vs. 39.1%, respectively). No correlation was found between size of ITDs and disease recurrence. More recurrences were seen in patients with irregularly shaped ITDs compared with patients with 1 or more smooth ITDs present.
conclusionsBecause of the high risk of disease recurrence, all node-negative stage II patients with ITDs, regardless of size and shape, should be classified as stage III, for whom adjuvant chemotherapy should be considered.
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