ArticleMolecular and cellular biochemistry2010
Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The hypothalamus as a therapeutic target: Towards novel approaches for managing antipsychotic-induced weight gain.Reviews in endocrine & metabolic disorders · 2026Review
- Role of the Genetic Variants of Fetuin-A and Adiponectin in Type 2 Diabetes Mellitus: A Narrative Review.Cureus · 2025Review
- The Role ofInternational journal of general medicine · 2025Article
- Regulation of Metabolic Health by an "Olfactory-Hypothalamic Axis" and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D.Cellular and molecular neurobiology · 2022Review
- Article
- The Complex Interactions Between Obesity, Metabolism and the Brain.Frontiers in neuroscience · 2019Review
- Hypothalamic AMPK and energy balance.European journal of clinical investigation · 2018Review
- Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.Scientific reports · 2017Article
- Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.Redox biology · 2017Review
- EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?European journal of endocrinology · 2017Review
- Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease.International journal of molecular sciences · 2017Review
- Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARPPAR research · 2017Article
- Caffeoylquinic Acid-Rich Extract ofPPAR research · 2017Article
- Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism.Experimental and therapeutic medicine · 2016Article
- Hypothalamic AMPK: a canonical regulator of whole-body energy balance.Nature reviews. Endocrinology · 2016Review
- The brain and brown fat.Annals of medicine · 2015Review
- New insight into adiponectin role in obesity and obesity-related diseases.BioMed research international · 2014Review
- mTOR and regulation of energy homeostasis in humans.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Article
- Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats.Journal of biomedical research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin is a newly researched adipokine which participates in the regulation of energy homeostasis. AMP-activated protein kinase (AMPK) represents an energy sensor that responds to hormone and nutrition status in vivo and exerts a regulatory effect in the hypothalamus and multiple peripheral tissues. We investigated the possible mechanisms involved in appetite regulation by adiponectin in vitro with GT1-7 cells, a mouse immortalized hypothalamic neuron. The results showed that adiponectin increased the phosphorylation of AMPK, activated AMPK phosphorylated and inactivated acetyl-CoA carboxylase (ACC), and subsequently increased expression of agouti-related peptide (AgRP) mRNA. Our results also indicated that adiponectin had no effect on signal transducer and activator of transcription (STAT3). Together these findings suggest that adiponectin regulated energy homeostasis through the AMPK/ACC pathway but not the JAK/STAT3 pathway in the hypothalamus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.