ArticleEuropean journal of nuclear medicine and molecular imaging2010
Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET.
Article in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 34 citations in OpenAlex.
- Quantification of myocardial blood flow with 82Rb positron emission tomography: clinical validation with 15O-water.European journal of nuclear medicine and molecular imaging · 2012Trial
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing.ESC heart failure · 2021Review
- Radiopharmaceutical tracers for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Anatomical and Functional Estimations of Brachial Artery Diameter and Elasticity Using Oscillometric Measurements with a Quantitative Approach.Pulse (Basel, Switzerland) · 2016Review
- Effects of continuous positive airway pressure treatment on coronary vasoreactivity measured by (82)Rb cardiac PET/CT in obstructive sleep apnea patients.Sleep & breathing = Schlaf & Atmung · 2016Article
- Thoracic fat volume is independently associated with coronary vasomotion.European journal of nuclear medicine and molecular imaging · 2016Article
- β2-adrenergic stress evaluation of coronary endothelial-dependent vasodilator function in mice using (11)C-acetate micro-PET imaging of myocardial blood flow and oxidative metabolism.EJNMMI research · 2014Article
- Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Coronary risk factors and myocardial blood flow in patients evaluated for coronary artery disease: a quantitative [15O]H2O PET/CT study.European journal of nuclear medicine and molecular imaging · 2012Article
- Effects of paraoxonase activity and gene polymorphism on coronary vasomotion.EJNMMI research · 2011Article
- On "ruby" in myocardial perfusion imaging.Journal of medical physics · 2011Article
- Assessment of coronary endothelial function using PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Review
- Coronary endothelial function: a clinical role for PET?European journal of nuclear medicine and molecular imaging · 2010Article
- Recent Progress in PET and SPECT Myocardial Perfusion Imaging: From Radiopharmaceuticals to Imaging Innovations.Iranian journal of pharmaceutical research : IJPRReview
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEndothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. 82Rb is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to (1) develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET, and (2) compare the results with those measured using 15O-water PET.
methodsMBF was assessed at rest and during the CPT with 82Rb and 15O-water in nine controls and ten smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during the CPT to MBF at rest.
resultsAt rest, measurements of MBF for smokers vs controls were not different using 15O-water (0.86±0.18 vs 0.70±0.13, p=0.426) than they were using 82Rb (0.83±0.23 vs 0.62±0.20, p=0.051). Both methods showed a reduced CPT response in smokers vs controls (15O-water, 1.03±0.21 vs 1.42±0.29, p=0.006; 82Rb, 1.02±0.28 vs 1.70±0.52, p<0.001). There was high reliability [intraclass correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during the CPT.
conclusionUsing a CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.
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