ArticleCurrent cardiovascular risk reports2010
High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality.
Article in Current cardiovascular risk reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides.Science translational medicine · 2020Article
- High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.Immunology · 2016Article
- A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry.Journal of proteome research · 2015Article
- HDL particle number and size as predictors of cardiovascular disease.Frontiers in pharmacology · 2015Review
- Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.Journal of medicinal chemistry · 2014Review
- Glycomic analysis of high density lipoprotein shows a highly sialylated particle.Journal of proteome research · 2014Article
- Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies.Molecular & cellular proteomics : MCP · 2013Article
- The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth.Diabetes · 2013Article
- The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.Structure (London, England : 1993) · 2012Article
- Serum amyloid A in uremic HDL promotes inflammation.Journal of the American Society of Nephrology : JASN · 2012Article
- Next stop for HDL: the lung.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- High density lipoprotein: it's not just about lipid transport anymore.Trends in endocrinology and metabolism: TEM · 2011Review
- Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography.Journal of proteome research · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent proteomics studies on human plasma high-density lipoprotein (HDL) have discovered up to 50 individual protein constituents. Many of these have known functions that vary surprisingly from the lipid transport roles commonly thought to mediate HDL's ability to protect from coronary artery disease. Given newly discovered roles in inflammation, protease inhibition, complement regulation, and innate immunity, many have begun to view HDL as a broad collection of distinct particle subfamilies, each distinguished by unique protein compositions and functions. Herein we review recent applications of high-resolution proteomics to HDL and summarize evidence supporting the idea of HDL functional subspeciation. These studies have set the stage for a more complete understanding of the molecular basis of HDL functional heterogeneity and hold promise for the identification of new biomarkers that can predict disease or evaluate the success of clinical interventions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.