ArticlePloS one2010
Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.Frontiers in toxicology · 2023Review
- Immunosuppressive Mechanisms of Regulatory B Cells.Frontiers in immunology · 2021Review
- CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody inAntibodies (Basel, Switzerland) · 2020Article
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.Journal of virology · 2019Article
- How to B(e)-1 Important Cell DuringFrontiers in cellular and infection microbiology · 2019Review
- Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.Frontiers in immunology · 2019Article
- Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Chronic Lymphocytic Leukemia-Derived IL-10 Suppresses Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Surface receptor Toso controls B cell-mediated regulation of T cell immunity.The Journal of clinical investigation · 2018Article
- Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.Immunology and cell biology · 2017Article
- Potential importance of B cells in aging and aging-associated neurodegenerative diseases.Seminars in immunopathology · 2017Review
- A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.JCI insight · 2016Article
- Close Encounters of Lymphoid Cells and Bacteria.Frontiers in immunology · 2016Review
- Role of B cells in host defense against primary Coxiella burnetii infection.Infection and immunity · 2015Article
- Role of B cell receptor signaling in IL-10 production by normal and malignant B-1 cells.Annals of the New York Academy of Sciences · 2015Article
- APRIL mediates peritoneal B-1 cell homeostasis.Immunology letters · 2014Article
- Toll-like receptors and B cells: functions and mechanisms.Immunologic research · 2014Review
- Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells.Immunology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
B cells are typically characterized as positive regulators of the immune response, primarily by producing antibodies. However, recent studies indicate that various subsets of B cells can perform regulatory functions mainly through IL-10 secretion. Here we discovered that peritoneal B-1 (B-1P) cells produce high levels of IL-10 upon stimulation with several Toll-like receptor (TLR) ligands. High levels of IL-10 suppressed B-1P cell proliferation and differentiation response to all TLR ligands studied in an autocrine manner in vitro and in vivo. IL-10 that accumulated in cultures inhibited B-1P cells at second and subsequent cell divisions mainly at the G1/S interphase. IL-10 inhibits TLR induced B-1P cell activation by blocking the classical NF-kappaB pathway. Co-stimulation with CD40 or BAFF abrogated the IL-10 inhibitory effect on B-1P cells during TLR stimulation. Finally, B-1P cells adoptively transferred from the peritoneal cavity of IL-10(-/-) mice showed better clearance of Borrelia hermsii than wild-type B-1P cells. This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.