GuidelineNeurology2010
Evidence-based guideline: The role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke [RETIRED]: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Guideline in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 119 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prognosis and distribution of ischemic stroke with negative diffusion-weighted imaging: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Systematic review of novel technology-based interventions for ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Most Common Publication Types of Neuroimaging Literature: Papers With High Levels of Evidence Are on the Rise.Frontiers in human neuroscience · 2020Pooled it
- Pooled it
- Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology and the Society of NeuroInterventional Surgery.Journal of the American College of Radiology : JACR · 2013Guideline
- A randomized comparison of two direct oral anticoagulants for patients undergoing cardiac ablation with a contemporary warfarin control arm.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Trial
- MRI before intraarterial therapy in ischemic stroke: feasibility, impact, and safety.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- To do or not to do; dilemma of intra-arterial revascularization in acute ischemic stroke.PloS one · 2014Trial
- Quantitative generation of diffusion-weighted imaging from non-contrast CT in acute ischemic stroke: a multi-scanner deep-learning model with external validation.Quantitative imaging in medicine and surgery · 2026Article
- Automated Diffusion-Weighted MRI Analysis for Exploratory Risk Stratification of Malignant Cerebral Edema After Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- The potential value of serum neuron-specific enolase in screening for silent cerebral infarction following radiofrequency catheter ablation for atrial fibrillation.BMC cardiovascular disorders · 2026Article
- Limitations and Blind Spots of Diffusion-Weighted Imaging in the Evaluation of Acute Brain Ischemia: A Narrative Review.Journal of clinical medicine · 2026Review
- Article
- The imaging-quiescent phenotype in thrombolysed acute ischemic stroke: a diffusion-weighted MRI-based deconstruction.Frontiers in neuroscience · 2026Article
- Current state and advancements of imaging in acute ischemic stroke: a practical review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Evaluating Deep Learning-Based Commercial Software for Detecting Ischemic Lesions on DWI in Stroke Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Predictor value of pCASL maps on final core in acute ischemic stroke: an observational single‑center study.Neuroradiology · 2025Observational
- Reversibility of diffuse magnetic resonance imaging following endovascular therapy in acute ischemic stroke: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- SDS-Net: A Synchronized Dual-Stage Network for Predicting Patients Within 4.5-h Thrombolytic Treatment Window Using MRI.Journal of imaging informatics in medicine · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
objectiveTo assess the evidence for the use of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) in the diagnosis of patients with acute ischemic stroke.
methodsWe systematically analyzed the literature from 1966 to January 2008 to address the diagnostic and prognostic value of DWI and PWI. RESULTS AND RECOMMENDATIONS: DWI is established as useful and should be considered more useful than noncontrast CT for the diagnosis of acute ischemic stroke within 12 hours of symptom onset. DWI should be performed for the most accurate diagnosis of acute ischemic stroke (Level A); however, the sensitivity of DWI for the diagnosis of ischemic stroke in a general sample of patients with possible acute stroke is not perfect. The diagnostic accuracy of DWI in evaluating cerebral hemorrhage is outside the scope of this guideline. On the basis of Class II and III evidence, baseline DWI volumes probably predict baseline stroke severity in anterior territory stroke (Level B) but possibly do not in vertebrobasilar artery territory stroke (Level C). Baseline DWI lesion volumes probably predict (final) infarct volumes (Level B) and possibly predict early and late clinical outcome measures (Level C). Baseline PWI volumes predict to a lesser degree the baseline stroke severity compared with DWI (Level C). There is insufficient evidence to support or refute the value of PWI in diagnosing acute ischemic stroke (Level U).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.