ArticleAntimicrobial agents and chemotherapy2010
Purification and characterization of avian beta-defensin 11, an antimicrobial peptide of the hen egg.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Nutritional and bioactive properties of native chicken eggs: Global perspectives on human health implications.Poultry science · 2026Review
- Effect of combined infection withOpen veterinary journal · 2024Article
- Article
- Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization.Frontiers in immunology · 2022Review
- Resistance-Nodulation-Cell Division (RND) Transporter AcrD Confers Resistance to Egg White inFoods (Basel, Switzerland) · 2021Article
- RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen.BMC genomics · 2021Article
- The Role of Ovotransferrin in Egg-White Antimicrobial Activity: A Review.Foods (Basel, Switzerland) · 2021Review
- Structure, function, and evolution ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Egg-White Proteins Have a Minor Impact on the Bactericidal Action of Egg White TowardFrontiers in microbiology · 2020Article
- The anti-bacterial iron-restriction defence mechanisms of egg white; the potential role of three lipocalin-like proteins in resistance against Salmonella.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
- The Golden Egg: Nutritional Value, Bioactivities, and Emerging Benefits for Human Health.Nutrients · 2019Review
- The Unique Features of Proteins Depicting the Chicken Amniotic Fluid.Molecular & cellular proteomics : MCP · 2019Article
- Transcriptional Sequencing Uncovers Survival Mechanisms of Salmonella enterica Serovar Enteritidis in Antibacterial Egg White.mSphere · 2019Article
- Proteomic analysis of egg white heparin-binding proteins: towards the identification of natural antibacterial molecules.Scientific reports · 2016Article
- Evolution of the avian β-defensin and cathelicidin genes.BMC evolutionary biology · 2015Article
- Article
- Antimicrobial peptides in reptiles.Pharmaceuticals (Basel, Switzerland) · 2014Article
- Three-dimensional NMR structure of Hen Egg Gallin (Chicken Ovodefensin) reveals a new variation of the β-defensin fold.The Journal of biological chemistry · 2014Article
- Ovalbumin-related protein X is a heparin-binding ov-serpin exhibiting antimicrobial activities.The Journal of biological chemistry · 2013Article
- Temporal changes in the expression of avian β-defensins in the chicken vagina during sexual maturation and Salmonella infection.Veterinary research communications · 2013Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Natural antimicrobial peptides are present in different compartments (eggshell, egg white, and vitelline membranes) of the hen egg and are expected to be involved in the protection of the embryo during its development and to contribute to the production of pathogen-free eggs. In the present study, we used vitelline membranes from hen (Gallus gallus) eggs as a source of avian β-defensin 11 (AvBD11). A purification scheme using affinity chromatography and reverse-phase chromatography was developed. Purified AvBD11 was analyzed by a combination of mass spectrometry approaches to characterize its primary sequence and structure. A monoisotopic molecular species at [M + H](+) of 9,271.56 Da was obtained, and its N- and C-terminal sequences were determined. We also examined posttranslational modifications and identified the presence of 6 internal disulfide bonds. AvBD11 was found to exhibit antimicrobial activity toward both Gram-positive and Gram-negative bacteria.
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