ArticleArchives of neurology2010
A summary risk score for the prediction of Alzheimer disease in elderly persons.
Article in Archives of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 7 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
101 citing papers in PubMed, 7 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Association between apolipoprotein E ε4 status and the risk of Alzheimer's disease: a meta-analysis.BMC neuroscience · 2025Pooled it
- Cardiovascular disease risk models and dementia or cognitive decline: a systematic review.Frontiers in aging neuroscience · 2023Pooled it
- Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis.Translational psychiatry · 2020Pooled it
- Combining Geospatial Analysis with Dementia Risk Utilising General Practice Data: A Systematic Review.The journal of prevention of Alzheimer's disease · 2018Pooled it
- Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2017Pooled it
- Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review.PloS one · 2015Pooled it
- Cardiovascular disease risk models and longitudinal changes in cognition: a systematic review.PloS one · 2014Pooled it
- Genetic risk score based on the lifetime prevalence of femoral fracture in 924 consecutive autopsies of Japanese males.Journal of bone and mineral metabolism · 2016Trial
- Late-life depression, mild cognitive impairment, and dementia.JAMA neurology · 2013Trial
- A risk prediction model using preoperative CT-based muscle and bone status for mortality and readmission after cardiac surgery in older patients.General thoracic and cardiovascular surgery · 2026Article
- Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Plasma phosphorylated tau 181, vascular risk factors, and cognition in elderly Hispanics.Journal of Alzheimer's disease : JAD · 2026Article
- Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in diverse populations.medRxiv : the preprint server for health sciences · 2026Article
- Exploring the pathogenic mechanisms of dementia risk factors: a task-fMRI study of mild cognitive impairment.Frontiers in neuroscience · 2026Article
- Neighborhood social cohesion and Alzheimer's disease dementia risk in South Asians in the United States.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Mixture Disease Progression Model to Predict and Cluster the Long-Term Trajectory of Cognitive Decline in Alzheimer's Disease.Therapeutic innovation & regulatory science · 2025Article
- Reclassification of the conventional risk assessment for aging-related diseases by electrocardiogram-enabled biological age.npj aging · 2025Article
- Development and validation of the Florey Dementia Risk Score web-based tool to screen for Alzheimer's disease in primary care.EClinicalMedicine · 2024Article
- Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement.Genome medicine · 2024Article
- The effectiveness of virtual passport, an app-based intervention, for dementia care.Frontiers in psychiatry · 2024Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles.
designA longitudinal, community-based study.
settingNew York, New York. Patients One thousand fifty-one Medicare recipients aged 65 years or older and residing in New York who were free of dementia or cognitive impairment at baseline.
main outcome measuresWe separately explored the associations of several vascular risk factors with late-onset Alzheimer disease (LOAD) using Cox proportional hazards models to identify factors that would contribute to the risk score. Then we estimated the score values of each factor based on their beta coefficients and created the LOAD vascular risk score by summing these individual scores.
resultsRisk factors contributing to the risk score were age, sex, education, ethnicity, APOE epsilon4 genotype, history of diabetes, hypertension or smoking, high-density lipoprotein levels, and waist to hip ratio. The resulting risk score predicted dementia well. According to the vascular risk score quintiles, the risk to develop probable LOAD was 1.0 for persons with a score of 0 to 14 and increased 3.7-fold for persons with a score of 15 to 18, 3.6-fold for persons with a score of 19 to 22, 12.6-fold for persons with a score of 23 to 28, and 20.5-fold for persons with a score higher than 28.
conclusionsWhile additional studies in other populations are needed to validate and further develop the score, our study suggests that this vascular risk score could be a valuable tool to identify elderly individuals who might be at risk of LOAD. This risk score could be used to identify persons at risk of LOAD, but can also be used to adjust for confounders in epidemiologic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.