Evidence map›Paper›PMID 20625085›Full record

ArticleArchives of neurology2010

Serum vitamin D and the risk of Parkinson disease.

Paul Knekt, Annamari Kilkkinen, Harri Rissanen, Jukka Marniemi, Katri Sääksjärvi, Markku Heliövaara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 6 pooled it
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 6 syntheses or guidelines pooled it, 3 citations in OpenAlex.

  1. The Association Between Vitamin D Status, Vitamin D Supplementation, Sunlight Exposure, and Parkinson's Disease: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015
    Pooled it
  5. Vitamin D status and Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014
    Pooled it
  6. Pooled it
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Temperature fluctuations and genetic influences on Parkinson's disease: a comprehensive analysis of temperature variability and time spent outdoors in the United States (1999-2023).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  12. Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Paul KnektNational Institute for Health and Welfare, Helsinki, Finland. paul.knekt@thl.fi
Annamari Kilkkinen
Harri Rissanen
Jukka Marniemi
Katri Sääksjärvi
Markku Heliövaara
Finnish Institute for Health and Welfare · FI

Funding

Organochlorine pesticide, PCBs, and ParkinsonsR01ES012667 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2005 to 2007
$1.0M
NIEHS NIH HHS R01 ES012667
6 · The paper itself

Abstract

objectiveTo investigate whether serum vitamin D level predicts the risk of Parkinson disease.

designCohort study.

settingThe study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model.

participantsThree thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence.

resultsIndividuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw.

conclusionsThe results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed.

Indexed as

AgedFemaleFinlandHealth SurveysHumansIncidenceLongitudinal StudiesMaleMiddle AgedParkinson DiseaseProportional Hazards ModelsVitamin D25-hydroxyvitamin DVitamin D

Identifiers

PMID20625085
PMCPMC3091074
OpenAlexW1220174533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.