Trial reportArchives of internal medicine2010
An intensive behavioral weight loss intervention and hot flushes in women.
Trial report in Archives of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00091988 (Program to Reduce Incontinence by Diet and Exercise), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Program to Reduce Incontinence by Diet and Exercise
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- [Preventive activities in women: PAPPS 2024 update].Atencion primaria · 2024Guideline
- Assessing the Acceptability and Effectiveness of Mobile-Based Physical Activity Interventions for Midlife Women During Menopause: Systematic Review of the Literature.JMIR mHealth and uHealth · 2022Pooled it
- Guideline
- Lifestyle interventions for the treatment of urinary incontinence in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Exercise for vasomotor menopausal symptoms.The Cochrane database of systematic reviews · 2014Pooled it
- Behavioral weight loss for the management of menopausal hot flashes: a pilot study.Menopause (New York, N.Y.) · 2015Trial
- Efficacy of exercise for menopausal symptoms: a randomized controlled trial.Menopause (New York, N.Y.) · 2014Trial
- Effect of aerobic training on hot flushes and quality of life--a randomized controlled trial.Annals of medicine · 2012Trial
- Effect of postdiagnosis weight change on hot flash status among early-stage breast cancer survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Experiences of hot flashes, urinary incontinence and mood among South Asian American women: the MASALA study.Climacteric : the journal of the International Menopause Society · 2025Observational
- Management of vasomotor symptoms in cancer patients.The oncologist · 2025Review
- Sleep, Mood, and Nutrition Patterns of Postmenopausal Women Diagnosed with Major Depressive Disorder by Menopause Periods.Life (Basel, Switzerland) · 2024Article
- Review
- Clinical guidelines for managing menopausal symptoms in women with (a history of) breast cancer.Facts, views & vision in ObGyn · 2023Article
- Comparison of predictive effect of the dietary inflammatory index and empirically derived food-based dietary inflammatory index on the menopause-specific quality of life and its complications.BMC women's health · 2023Article
- Evidence and consensus-based clinical practice guidelines for management of overweight and obesity in midlife women: An AIIMS-DST initiative.Journal of family medicine and primary care · 2022Review
- [Preventive activities in women. PAPPS update 2022].Atencion primaria · 2022Article
- A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study.Menopause (New York, N.Y.) · 2020Article
- [Preventive activities in women's care].Atencion primaria · 2020Article
- Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update.Ecancermedicalscience · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear.
methodsSelf-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors.
resultsApproximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89).
conclusionAmong women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control. Trial Registration clinicaltrials.gov Identifier: NCT00091988.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.