ArticleProceedings of the National Academy of Sciences of the United States of America2010
Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 31 citations in OpenAlex.
- Evidence for Stabilizing Selection Driving Mutational Turnover of Short Motifs in the Eukaryotic Complementary Sex Determiner (Csd) Protein.G3 (Bethesda, Md.) · 2018Article
- Uneven distribution of complementary sex determiner (csd) alleles in Apis mellifera population.Scientific reports · 2017Article
- The Cardamine hirsuta genome offers insight into the evolution of morphological diversity.Nature plants · 2016Article
- Correlated expression of retrocopies and parental genes in zebrafish.Molecular genetics and genomics : MGG · 2016Article
- Evolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade.PLoS genetics · 2016Article
- Article
- QTL Mapping of Sex Determination Loci Supports an Ancient Pathway in Ants and Honey Bees.PLoS genetics · 2015Article
- The evolutionary dynamics of major regulators for sexual development among Hymenoptera species.Frontiers in genetics · 2015Article
- Nucleotide variability at its limit? Insights into the number and evolutionary dynamics of the sex-determining specificities of the honey bee Apis mellifera.Molecular biology and evolution · 2014Article
- Independent evolutionary origin of fem paralogous genes and complementary sex determination in hymenopteran insects.PloS one · 2014Article
- Duplication and concerted evolution in a master sex determiner under balancing selection.Proceedings. Biological sciences · 2013Article
- Evolution of recombination and genome structure in eusocial insects.Communicative & integrative biology · 2013Article
- Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases.BMC evolutionary biology · 2012Article
- Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses.BMC evolutionary biology · 2012Article
- Patterns of selection and polymorphism of innate immunity genes in bumblebees (Hymenoptera: Apidae).Genetica · 2012Article
- Molecular evolution of Drosophila Sex-lethal and related sex determining genes.BMC evolutionary biology · 2012Article
- Extensive pyrosequencing reveals frequent intra-genomic variations of internal transcribed spacer regions of nuclear ribosomal DNA.PloS one · 2012Article
- Function and evolution of sex determination mechanisms, genes and pathways in insects.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Evolution: Gene duplicate holds back its sister.Nature reviews. Genetics · 2010Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most remarkable outcome of a gene duplication event is the evolution of a novel function. Little information exists on how the rise of a novel function affects the evolution of its paralogous sister gene copy, however. We studied the evolution of the feminizer (fem) gene from which the gene complementary sex determiner (csd) recently derived by tandem duplication within the honey bee (Apis) lineage. Previous studies showed that fem retained its sex determination function, whereas the rise of csd established a new primary signal of sex determination. We observed a specific reduction of nonsynonymous to synonymous substitution ratios in Apis to non-Apis fem. We found a contrasting pattern at two other genetically linked genes, suggesting that hitchhiking effects to csd, the locus under balancing selection, is not the cause of this evolutionary pattern. We also excluded higher synonymous substitution rates by relative rate testing. These results imply that stronger purifying selection is operating at the fem gene in the presence of csd. We propose that csd's new function interferes with the function of Fem protein, resulting in molecular constraints and limited evolvability of fem in the Apis lineage. Elevated silent nucleotide polymorphism in fem relative to the genome-wide average suggests that genetic linkage to the csd gene maintained more nucleotide variation in today's population. Our findings provide evidence that csd functionally and genetically interferes with fem, suggesting that a newly evolved gene and its functions can limit the evolutionary capability of other genes in the genome.
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