ArticleProceedings of the National Academy of Sciences of the United States of America2010
A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
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Who cites it
229 citing papers in PubMed.
- Genome-wide association mapping of tan spot resistance in a modified NAM population derived from synthetic hexaploid wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Two independent dominant resistance genes confer resistance to spot blotch in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Identification of septoria nodorum blotch susceptibility genes in hard winter wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The hijacking of a wheat Exo70-like protein by a fungal pathogen triggers disease.Nature communications · 2026Article
- Novel genomic regions associated with adult-plant resistance to multiple fungal pathogens in wheat (Triticum aestivum L.) revealed by DArT marker sequencing.Journal of applied genetics · 2026Article
- Genome wide association studies and expression analyses identify candidate genes for spot blotch resistance in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Resistance to the oat leaf blotch pathogen (Pyrenophora avenae) is delimited to a region of chromosome 1D that harbors a candidate resistance kinase fusion protein.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos.The New phytologist · 2026Article
- Global perspective on the genetic architecture of susceptibility to spot form net blotch in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- The Landscape of Integrated Domains of Angiosperm NLR Genes Reveals Continuous Architecture Evolution of Plant Intracellular Immune Receptors.Plants (Basel, Switzerland) · 2025Article
- The pan-NLRome and diversity of Watkins wheat provide genetic resources for improving disease resistance and adaptation.Plant communications · 2025Article
- Winning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.Plant biotechnology journal · 2025Review
- Genome-wide association mapping for resistance against Septoria nodorum blotch and tan spot in a diverse wheat panel.Molecular breeding : new strategies in plant improvement · 2025Article
- The Annotated Blueprint: Integrated Functional Genomic Resources for a model Tetraploid WheatbioRxiv : the preprint server for biology · 2025Article
- Development of diagnostic markers for the disease susceptibility gene Tsn1 in wheat reveals novel resistance alleles and a new locus required for ToxA sensitivity.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Nano Fat Therapy and Platelet Rich Plasma Versus Nano Fat Therapy Alone on Burn Scar.Annals of burns and fire disasters · 2025Article
- Silencing of disease susceptibility genes: an effective disease resistance strategy against fungal pathogens.Plant cell reports · 2025Review
- Structure-guided insights into the biology of fungal effectors.The New phytologist · 2025Review
- Abscisic Acid Can Play a Dual Role in thePlants (Basel, Switzerland) · 2025Article
169 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant disease resistance is often conferred by genes with nucleotide binding site (NBS) and leucine-rich repeat (LRR) or serine/threonine protein kinase (S/TPK) domains. Much less is known about mechanisms of susceptibility, particularly to necrotrophic fungal pathogens. The pathogens that cause the diseases tan spot and Stagonospora nodorum blotch on wheat produce effectors (host-selective toxins) that induce susceptibility in wheat lines harboring corresponding toxin sensitivity genes. The effector ToxA is produced by both pathogens, and sensitivity to ToxA is governed by the Tsn1 gene on wheat chromosome arm 5BL. Here, we report the cloning of Tsn1, which was found to have disease resistance gene-like features, including S/TPK and NBS-LRR domains. Mutagenesis revealed that all three domains are required for ToxA sensitivity, and hence disease susceptibility. Tsn1 is unique to ToxA-sensitive genotypes, and insensitive genotypes are null. Sequencing and phylogenetic analysis indicated that Tsn1 arose in the B-genome diploid progenitor of polyploid wheat through a gene-fusion event that gave rise to its unique structure. Although Tsn1 is necessary to mediate ToxA recognition, yeast two-hybrid experiments suggested that the Tsn1 protein does not interact directly with ToxA. Tsn1 transcription is tightly regulated by the circadian clock and light, providing further evidence that Tsn1-ToxA interactions are associated with photosynthesis pathways. This work suggests that these necrotrophic pathogens may thrive by subverting the resistance mechanisms acquired by plants to combat other pathogens.
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