ArticleThe Journal of cell biology2010
The phospholipase complex PAFAH Ib regulates the functional organization of the Golgi complex.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- CaFaculty reviews · 2022Review
- Endocytosis and Exocytosis inFrontiers in cellular and infection microbiology · 2020Article
- Lipid-dependent coupling of secretory cargo sorting and trafficking at the trans-Golgi network.FEBS letters · 2019Review
- Methods for analyzing the role of phospholipase A₂ enzymes in endosome membrane tubule formation.Methods in cell biology · 2015Article
- Gβ1γ2 activates phospholipase AFrontiers in cell and developmental biology · 2014Article
- Insulin-regulated protein palmitoylation impacts endothelial cell function.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Golgi tubules: their structure, formation and role in intra-Golgi transport.Histochemistry and cell biology · 2013Review
- PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function.Biochimica et biophysica acta · 2013Article
- Regulation of the Golgi complex by phospholipid remodeling enzymes.Biochimica et biophysica acta · 2012Review
- Modular organization of the mammalian Golgi apparatus.Current opinion in cell biology · 2012Review
- A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells.Molecular biology of the cell · 2012Article
- A PLA1-2 punch regulates the Golgi complex.Trends in cell biology · 2012Review
- A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Models for Golgi traffic: a critical assessment.Cold Spring Harbor perspectives in biology · 2011Review
- Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.Chemical reviews · 2011Review
- The phospholipase A₂ enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking.Molecular biology of the cell · 2011Article
- LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.PloS one · 2011Article
- A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking.Traffic (Copenhagen, Denmark) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
We report that platelet-activating factor acetylhydrolase (PAFAH) Ib, comprised of two phospholipase A(2) (PLA(2)) subunits, alpha1 and alpha2, and a third subunit, the dynein regulator lissencephaly 1 (LIS1), mediates the structure and function of the Golgi complex. Both alpha1 and alpha2 partially localize on Golgi membranes, and purified catalytically active, but not inactive alpha1 and alpha2 induce Golgi membrane tubule formation in a reconstitution system. Overexpression of wild-type or mutant alpha1 or alpha2 revealed that both PLA(2) activity and LIS1 are important for maintaining Golgi structure. Knockdown of PAFAH Ib subunits fragments the Golgi complex, inhibits tubule-mediated reassembly of intact Golgi ribbons, and slows secretion of cargo. Our results demonstrate a cooperative interplay between the PLA(2) activity of alpha1 and alpha2 with LIS1 to facilitate the functional organization of the Golgi complex, thereby suggesting a model that links phospholipid remodeling and membrane tubulation to dynein-dependent transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.