ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2010
The cost-effectiveness of screening for colorectal cancer.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Recommendations on screening for colorectal cancer in primary care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Guideline
- The usefulness of routine histopathology of bilateral nasal polyps - a systematic review, meta-analysis, and cost evaluation.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015Pooled it
- Trial
- Cost effectiveness analysis of three colorectal cancer screening modalities in Kuwait.Scientific reports · 2025Article
- Screening of healthcare staff for the prevention of colon cancer.Przeglad gastroenterologiczny · 2025Review
- Cost-effectiveness Analysis of Colorectal Cancer Screening Strategies Using Active Learning and Monte Carlo Simulation.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- An Exploratory Analysis of the Cost-Effectiveness of a Multi-cancer Early Detection Blood Test Compared with Standard of Care Screening in Ontario, Canada.PharmacoEconomics · 2024Article
- Calibration and Validation of the Colorectal Cancer and Adenoma Incidence and Mortality (CRC-AIM) Microsimulation Model Using Deep Neural Networks.Medical decision making : an international journal of the Society for Medical Decision Making · 2023Article
- The value of time-dependent risk predictions in a screening context - a comprehensive simulation analysis validated on German cancer registry data.BMC medical research methodology · 2022Article
- Unmet Healthcare Needs among College Students during the COVID-19 Pandemic: Implications for System-Wide and Structural Changes for Service Delivery.Healthcare (Basel, Switzerland) · 2022Article
- Canadian Colorectal Cancer Screening Guidelines: Do They Need an Update Given Changing Incidence and Global Practice Patterns?Current oncology (Toronto, Ont.) · 2021Review
- Comparative effectiveness and cost-effectiveness analysis of a urine metabolomics test vs. alternative colorectal cancer screening strategies.International journal of colorectal disease · 2019Article
- Cost-utility analysis of colonoscopy or faecal immunochemical test for population-based organised colorectal cancer screening.United European gastroenterology journal · 2019Article
- Patterns and predictors of adherence to colorectal cancer screening recommendations in Alberta's Tomorrow Project participants stratified by risk.BMC public health · 2018Article
- Characteristics of Patients with Colonic Polyps Requiring Segmental Resection.Canadian journal of gastroenterology & hepatology · 2018Article
- Cost-effectiveness of colorectal cancer screening in Ukraine.Cost effectiveness and resource allocation : C/E · 2018Article
- Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada.PLoS medicine · 2017Article
- Harms, benefits and costs of fecal immunochemical testing versus guaiac fecal occult blood testing for colorectal cancer screening.PloS one · 2017Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPublished decision analyses show that screening for colorectal cancer is cost-effective. However, because of the number of tests available, the optimal screening strategy in Canada is unknown. We estimated the incremental cost-effectiveness of 10 strategies for colorectal cancer screening, as well as no screening, incorporating quality of life, noncompliance and data on the costs and benefits of chemotherapy.
methodsWe used a probabilistic Markov model to estimate the costs and quality-adjusted life expectancy of 50-year-old average-risk Canadians without screening and with screening by each test. We populated the model with data from the published literature. We calculated costs from the perspective of a third-party payer, with inflation to 2007 Canadian dollars.
resultsOf the 10 strategies considered, we focused on three tests currently being used for population screening in some Canadian provinces: low-sensitivity guaiac fecal occult blood test, performed annually; fecal immunochemical test, performed annually; and colonoscopy, performed every 10 years. These strategies reduced the incidence of colorectal cancer by 44%, 65% and 81%, and mortality by 55%, 74% and 83%, respectively, compared with no screening. These strategies generated incremental cost-effectiveness ratios of $9159, $611 and $6133 per quality-adjusted life year, respectively. The findings were robust to probabilistic sensitivity analysis. Colonoscopy every 10 years yielded the greatest net health benefit.
interpretationScreening for colorectal cancer is cost-effective over conventional levels of willingness to pay. Annual high-sensitivity fecal occult blood testing, such as a fecal immunochemical test, or colonoscopy every 10 years offer the best value for the money in Canada.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.