ArticleGenome biology and evolution2010
Evolution of a bitter taste receptor gene cluster in a New World sparrow.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- The evolution of structural variation across 500 million years of vertebrate evolution.bioRxiv : the preprint server for biology · 2026Article
- Activation of Extraoral Bitter Taste Receptors by Herbs and Spices in the Regulation of Incretin Signaling and Glucose Metabolism.Nutrition reviews · 2026Review
- Functional Decline of a Bitter Receptor Gene in New World Vultures.Molecular biology and evolution · 2025Article
- Taste receptors and their ecological niches: cats, dogs, and other vertebrates.Chemical senses · 2025Review
- Relationships between Bitter Taste Receptor Gene Evolution, Diet, and Gene Repertoire in Primates.Genome biology and evolution · 2024Article
- The evolution of bitter taste receptor gene in primates: Gene duplication and selection.Ecology and evolution · 2023Article
- The avian taste system.Frontiers in physiology · 2023Review
- Bitter taste receptors of the zebra finch (Frontiers in physiology · 2023Article
- Darwin's small and medium ground finches might have taste preferences, but not for human foods.Royal Society open science · 2022Article
- Activation of the Nucleus Taeniae of the Amygdala by Umami Taste in Domestic Chicks (Frontiers in physiology · 2022Article
- Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021Review
- Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors inBioMed research international · 2019Article
- Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats.Molecular ecology · 2018Article
- Lineage-specific evolution of bitter taste receptor genes in the giant and red pandas implies dietary adaptation.Integrative zoology · 2018Article
- Article
- Birds Generally Carry a Small Repertoire of Bitter Taste Receptor Genes.Genome biology and evolution · 2015Article
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- BitterDB: a database of bitter compounds.Nucleic acids research · 2012Article
- Article
- Comparative BAC-based mapping in the white-throated sparrow, a novel behavioral genomics model, using interspecies overgo hybridization.BMC research notes · 2011Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Bitter taste perception likely evolved as a protective mechanism against the ingestion of harmful compounds in food. The evolution of the taste receptor type 2 (TAS2R) gene family, which encodes the chemoreceptors that are directly responsible for the detection of bitter compounds, has therefore been of considerable interest. Though TAS2R repertoires have been characterized for a number of species, to date the complement of TAS2Rs from just one bird, the chicken, which had a notably small number of TAS2Rs, has been established. Here, we used targeted mapping and genomic sequencing in the white-throated sparrow (Zonotrichia albicollis) and sample sequencing in other closely related birds to reconstruct the history of a TAS2R gene cluster physically linked to the break points of an evolutionary chromosomal rearrangement. In the white-throated sparrow, this TAS2R cluster encodes up to 18 functional bitter taste receptors and likely underwent a large expansion that predates and/or coincides with the radiation of the Emberizinae subfamily into the New World. In addition to signatures of gene birth-and-death evolution within this cluster, estimates of Ka/Ks for the songbird TAS2Rs were similar to those previously observed in mammals, including humans. Finally, comparison of the complete genomic sequence of the cluster from two common haplotypes in the white-throated sparrow revealed a number of nonsynonymous variants and differences in functional gene content within this species. These results suggest that interspecies and intraspecies genetic variability does exist in avian TAS2Rs and that these differences could contribute to variation in bitter taste perception in birds.
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