ArticleGenome biology and evolution2010
Relative contributions of intrinsic structural-functional constraints and translation rate to the evolution of protein-coding genes.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Functional Optimization in Distinct Tissues and Conditions Constrains the Rate of Protein Evolution.Molecular biology and evolution · 2024Article
- Asymmetric Evolution of Protein Domains in the Leucine-Rich Repeat Receptor-Like Kinase Family of Plant Signaling Proteins.Molecular biology and evolution · 2023Article
- Proteomic Analyses Provide Novel Insights into Plant Growth and Ginsenoside Biosynthesis in Forest Cultivated Panax ginseng (F. Ginseng).Frontiers in plant science · 2016Article
- Universal distribution of mutational effects on protein stability, uncoupling of protein robustness from sequence evolution and distinct evolutionary modes of prokaryotic and eukaryotic proteins.Physical biology · 2015Article
- Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs.Molecular biology and evolution · 2014Article
- Evolution of a morphological novelty occurred before genome compaction in a lineage of extreme parasites.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Conserved proteins are fragile.Molecular biology and evolution · 2014Article
- Identification of expressed and conserved human noncoding RNAs.RNA (New York, N.Y.) · 2014Article
- Determinants of exon-level evolutionary rates in Arabidopsis species.Evolutionary bioinformatics online · 2012Article
- Predictability of evolutionary trajectories in fitness landscapes.PLoS computational biology · 2011Article
- Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins.Biology direct · 2011Article
- Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy.Proceedings. Biological sciences · 2011Review
- Negative correlation between expression level and evolutionary rate of long intergenic noncoding RNAs.Genome biology and evolution · 2011Article
- Impact of translational error-induced and error-free misfolding on the rate of protein evolution.Molecular systems biology · 2010Article
- Constraints and plasticity in genome and molecular-phenome evolution.Nature reviews. Genetics · 2010Review
- Expression level, evolutionary rate, and the cost of expression.Genome biology and evolution · 2010Article
- The effect of chaperonin buffering on protein evolution.Genome biology and evolution · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A long-standing assumption in evolutionary biology is that the evolution rate of protein-coding genes depends, largely, on specific constraints that affect the function of the given protein. However, recent research in evolutionary systems biology revealed unexpected, significant correlations between evolution rate and characteristics of genes or proteins that are not directly related to specific protein functions, such as expression level and protein-protein interactions. The strongest connections were consistently detected between protein sequence evolution rate and the expression level of the respective gene. A recent genome-wide proteomic study revealed an extremely strong correlation between the abundances of orthologous proteins in distantly related animals, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. We used the extensive protein abundance data from this study along with short-term evolutionary rates (ERs) of orthologous genes in nematodes and flies to estimate the relative contributions of structural-functional constraints and the translation rate to the evolution rate of protein-coding genes. Together the intrinsic constraints and translation rate account for approximately 50% of the variance of the ERs. The contribution of constraints is estimated to be 3- to 5-fold greater than the contribution of translation rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.