Evidence map›Paper›PMID 20624597›Full record

ArticleNeuron2010

Endogenous electric fields may guide neocortical network activity.

Flavio Fröhlich, David A McCormick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 405 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
405citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

405 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  15. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
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345 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Flavio FröhlichDepartment of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
David A McCormick

Funding

Neurotransmitter Actions in Neocortex and ThalamusR37NS026143 · NINDS · YALE UNIVERSITY · PI MCCORMICK, DAVID · 2005 to 2011
$3.0M
NINDS NIH HHS R37 NS026143
6 · The paper itself

Abstract

Local field potentials and the underlying endogenous electric fields (EFs) are traditionally considered to be epiphenomena of structured neuronal network activity. Recently, however, externally applied EFs have been shown to modulate pharmacologically evoked network activity in rodent hippocampus. In contrast, very little is known about the role of endogenous EFs during physiological activity states in neocortex. Here, we used the neocortical slow oscillation in vitro as a model system to show that weak sinusoidal and naturalistic EFs enhance and entrain physiological neocortical network activity with an amplitude threshold within the range of in vivo endogenous field strengths. Modulation of network activity by positive and negative feedback fields based on the network activity in real-time provide direct evidence for a feedback loop between neuronal activity and endogenous EF. This significant susceptibility of active networks to EFs that only cause small changes in membrane potential in individual neurons suggests that endogenous EFs could guide neocortical network activity.

Indexed as

AnimalsComputer SimulationElectric StimulationEvoked PotentialsFerretsIn Vitro TechniquesMaleModels, NeurologicalNeocortexNerve NetNeuronsNonlinear DynamicsOscillometry

Identifiers

PMID20624597
PMCPMC3139922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.