ArticleDevelopmental biology2010
Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
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- Δ133p53 coordinates ECM-driven morphogenesis and gene expression in three-dimensional mammary epithelial acini.Journal of cell science · 2022Article
- An In Vitro Approach for Investigating the Safety of Lipotransfer after Breast-Conserving Therapy.Journal of personalized medicine · 2022Article
- Fibronectin assembly regulates lumen formation in breast acini.Journal of cellular biochemistry · 2021Article
- Shear-Regulated Extracellular Microenvironments and Endothelial Cell Surface Integrin Receptors Intertwine in Atherosclerosis.Frontiers in cell and developmental biology · 2021Review
- Mammary epithelial morphogenesis in 3D combinatorial microenvironments.Scientific reports · 2020Article
- Impact of Fibronectin Knockout on Proliferation and Differentiation of Human Infrapatellar Fat Pad-Derived Stem Cells.Frontiers in bioengineering and biotechnology · 2019Article
- Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Neural crest cell-autonomous roles of fibronectin in cardiovascular development.Development (Cambridge, England) · 2016Article
- Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.The American journal of pathology · 2015Article
- Dynamic reciprocity between cells and their microenvironment in reproduction.Biology of reproduction · 2015Review
- CD151 represses mammary gland development by maintaining the niches of progenitor cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Integrins in renal development.Pediatric nephrology (Berlin, Germany) · 2012Review
- Acute milk yield response to frequent milking during early lactation is mediated by genes transiently regulated by milk removal.Physiological genomics · 2012Article
- β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Molecular biology of the cell · 2011Article
- Extracellular matrix receptors in branched organs.Current opinion in cell biology · 2011Review
- Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.Journal of mammary gland biology and neoplasia · 2011Review
- A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Fibronectin (Fn) plays an important part in the branching morphogenesis of salivary gland, lung, and kidney. Here, we examine the effect of the conditional knockout of Fn in the mammary epithelium [Fn(MEp-/-)] on postnatal mammary gland development, using Cre-loxP-mediated gene knockout technology. Our data show that Fn deletion causes a moderate retardation in outgrowth and branching of the ductal tree in 5-week-old mice. These defects are partially compensated in virgin 16-week-old mice. However, mammary glands consisting of Fn-deficient epithelial cells fail to undergo normal lobuloalveolar differentiation during pregnancy. The severity of lobuloalveolar impairment ranged from lobular hypoplasia to aplasia in some cases and was associated with the amount of Fn protein recovered from these glands. Decreased rates of mammary epithelial cell proliferation accounted for delayed ductal outgrowth in virgin and lack of alveologenesis in pregnant Fn(MEp-/-) mice. Concomitant decreased expression of integrin beta(1) (Itgb1) and lack of autophosphorylation of focal adhesion kinase (Fak) suggest that this pathology might, at least in part, be mediated by disruption of the Fn/Itgb1/Fak signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.