Evidence map›Paper›PMID 20623546›Full record

ReviewBioFactors (Oxford, England)

Resveratrol: Biological and pharmaceutical properties as anticancer molecule.

Tze-chen Hsieh, Joseph M Wu

Abstract readReview
In one paragraph

Review in BioFactors (Oxford, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Review on Natural Agents as Aromatase Inhibitors: Management of Breast Cancer.Combinatorial chemistry & high throughput screening · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Resveratrol and Brain Mitochondria: a Review.Molecular neurobiology · 2018
    Review
  20. Natural Products for the Management and Prevention of Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tze-chen HsiehDepartment of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA.
Joseph M Wu

Funding

RETINOIDS AND EPITHELIAL DIFFERENTIATIONP30CA029502 · NCI · STRANG CANCER PREVENTION CENTER · PI RIVLIN, RICHARD S · 2002 to 2006
$4.1M
ZINC AS A BIOLOGICAL RESPONSE MODIFIERP01CA029502 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI CUNNINGHAM-RUNDLES, SUSANNA · 1985 to 2000
$360k
Novel target proteins of resveratrol in chemopreventionR21CA104425 · NCI · NEW YORK MEDICAL COLLEGE · PI WU, JOSEPH M · 2004 to 2005
$280k
Chemoprevention of prostate cancer by resveratrolR03CA109932 · NCI · NEW YORK MEDICAL COLLEGE · PI HSIEH, TZE-CHEN · 2004 to 2005
$156k
NCI NIH HHS CA104424NCI NIH HHS CA109932NCI NIH HHS CA29502NCI NIH HHS P01 CA029502NCI NIH HHS P30 CA029502NCI NIH HHS R03 CA109932NCI NIH HHS R21 CA104425
6 · The paper itself

Abstract

There is ample evidence that shows an inverse relationship between consumption of fruit/vegetable-rich diets and the risk of cancer at various anatomical sites. In this review, we will assess and summarize recent advances on cancer prevention by resveratrol, a natural stilbenoid present in red grapes, peanuts, some common drinks, and dietary supplements. We will focus on data published within the past few years on in vivo model tumor animal studies that reinforce the chemopreventive efficacy of resveratrol against a multitude of cancers, as well as on its sensitization/enhancing activities against tumor cells when used in combination with established chemotherapeutic and pharmaceutical agents. In addition, we will review examples resveratrol-target proteins, denoted RTPs, including the 24-kDa cytosolic protein quinone reductase 2 (NQO2) discovered in our laboratory that may confer resveratrol responsiveness to cancer cells. We will discuss the possible role of NQO2 in mediating cancer prevention by resveratrol. Our analysis of published data strengthen support that resveratrol displays novel roles in various cellular processes, and help to establish an expanded molecular framework for cancer prevention by resveratrol in vivo.

Indexed as

AnimalsAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicBiological AvailabilityBreast NeoplasmsDietFemaleHumansMaleNeoplasmsProstatic NeoplasmsQuinone ReductasesRadiation-Sensitizing AgentsResveratrolSignal TransductionStilbenesAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicNRH - quinone oxidoreductase2Quinone ReductasesRadiation-Sensitizing AgentsResveratrolStilbenesTNF-Related Apoptosis-Inducing Ligand

Identifiers

PMID20623546
PMCPMC3655417

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.