ArticlePharmacoepidemiology and drug safety2010
Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: a population-based case-control study.
Article in Pharmacoepidemiology and drug safety, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Pooled it
- Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children.The Journal of pediatrics · 2013Trial
- Review
- Drug Related Problems among Older Inpatients at a Tertiary Care Setting.Journal of clinical medicine · 2024Article
- Article
- Assessment of Prescriptions in Elderly Patients Hospitalized in Medicine Departments.Journal of clinical medicine · 2021Article
- Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Proton Pump Inhibitors and Infection-Related Hospitalizations Among Residents of Long-Term Care Facilities: A Case-Control Study.Drugs & aging · 2019Article
- Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence.Therapeutic advances in drug safety · 2017Review
- Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.Clinical drug investigation · 2017Review
- Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study.BMJ (Clinical research ed.) · 2016Article
- Risk of community-acquired pneumonia in patients with a diagnosis of pernicious anemia: a population-based retrospective cohort study.European journal of gastroenterology & hepatology · 2015Article
- Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs: A Population-Based Cohort Study.Medicine · 2015Article
- The impact of acid-suppressing drugs to the patients with chronic obstructive pulmonary disease: A nationwide, population-based, cohort study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Article
- Effects of proton pump inhibitors on lung cancer precise radiotherapy-induced radiation pneumonitis.Cell biochemistry and biophysics · 2014Article
- Angiotensin-converting enzyme inhibitor use and pneumonia risk in community-dwelling older adults: results from a population-based case-control study.Pharmacoepidemiology and drug safety · 2012Article
- Factors associated with the initiation of proton pump inhibitors in corticosteroid users.Pharmacoepidemiology and drug safety · 2012Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo examine whether use of proton pump inhibitors (PPIs) and H2 blockers is associated with increased pneumonia risk.
methodsWe conducted a population-based, nested case-control study within Group Health, an integrated healthcare delivery system. Among community-dwelling, immunocompetent adults aged 65-94, we identified presumptive cases of ambulatory and hospitalized community-acquired pneumonia in 2000-2003 from ICD-9 codes and validated them by medical record review (N = 1125). Controls were selected, matched to cases on age, sex, and calendar year (N = 2235). Current PPI or H2 blocker use was ascertained from computerized pharmacy records. Comorbid illnesses and other characteristics were ascertained by medical record review. Multivariable conditional logistic regression was used to examine the association between medication use and pneumonia risk. We conducted sensitivity analyses using only administrative and pharmacy data to assess how these results differed from our primary results.
resultsThe prevalence of PPI or H2 blocker use was 21% (241/1125) for pneumonia cases and 16% (350/2235) for controls (adjusted odds ratio [OR] 1.03, 95% CI 0.86-1.24, compared to nonuse). No increased risk was seen for recent initiation. The prevalence of PPI use was 12% (132/1125) for cases and 7% (160/2235) for controls (adjusted OR 1.13, 95% CI 0.88-1.44). Analyses using only administrative and pharmacy data yielded risk estimates farther from the null (adjusted OR 1.32, 95% CI 1.17-1.49, for current PPI use versus nonuse).
conclusionsUse of PPIs and H2 blockers is not associated with increased pneumonia risk in older adults. The increased risk observed in some prior studies may reflect confounding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.