ArticleSynapse (New York, N.Y.)2011
A behavioral and molecular analysis of ketamine in zebrafish.
Article in Synapse (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- Preliminary Data Regarding the Alleviating Effects of Haloperidol and Risperidone on the Short-Term Memory and Associative Learning in a Zebrafish Model of Schizophrenia.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity.Environmental science and ecotechnology · 2024Article
- Article
- Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies.Current neuropharmacology · 2022Review
- A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants.Progress in neurobiology · 2021Article
- Rapid well-plate assays for motor and social behaviors in larval zebrafish.Behavioural brain research · 2020Article
- The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research.Frontiers in psychiatry · 2020Review
- Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.Clinics (Sao Paulo, Brazil) · 2020Article
- Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity.Frontiers in pharmacology · 2019Article
- Article
- Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine.Psychopharmacology · 2017Article
- The Non-Peptide Arginine-Vasopressin vFrontiers in psychiatry · 2017Article
- Zebrafish as an emerging model for studying complex brain disorders.Trends in pharmacological sciences · 2014Review
- Effects of midazolam, pentobarbital and ketamine on the mRNA expression of ion channels in a model organism Daphnia pulex.BMC anesthesiology · 2013Article
- Topographical analysis of reactive zinc in the central nervous system of adult zebrafish (Danio rerio).Zebrafish · 2013Article
- Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds.ACS chemical neuroscience · 2013Review
- Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish.Journal of applied toxicology : JAT · 2013Article
- ZebraZoom: an automated program for high-throughput behavioral analysis and categorization.Frontiers in neural circuits · 2013Article
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology.Progress in neuro-psychopharmacology & biological psychiatry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Ketamine exerts powerful anesthetic, psychotic, and antidepressant effects in both healthy volunteers and clinically depressed patients. Although ketamine targets particular glutamate receptors, there is a dearth of evidence for additional, alternative molecular substrates for the behavioral actions of this N-methyl-D-aspartate (NMDA) receptor antagonist drug. Here, we provide behavioral and molecular evidence for the actions of ketamine using a new vertebrate model for psychiatric disorders: the zebrafish. Subanesthetic doses of ketamine produced a variety of abnormal behaviors in zebrafish that were qualitatively analogous to those previously measured in humans and rodents treated with drugs that produce transient psychosis. In addition, we revealed that the transcription factor Phox2b is a molecular substrate for the actions of ketamine, particularly during periods of hypoxic stress. Finally, we also show that SIRT1, a histone deacetylase widely recognized for its link to cell survival is also affected by hypoxia crises. These results establish a relevant assay system in which the effects of psychotomimetic drugs can rapidly be assessed, and provide a plausible and novel neuronal mechanism through which ketamine affects critical sensory circuits that monitor breathing behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.