ArticleEuropean journal of epidemiology2010
Spatial clustering and space-time clusters of leukemia among children in Germany, 1987-2007.
Article in European journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Space-time clustering of childhood cancers: a systematic review and pooled analysis.European journal of epidemiology · 2019Pooled it
- Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.Frontiers in oncology · 2024Article
- Evidence-Based Conceptual Collection of Methods for Spatial Epidemiology and Analysis to Enhance Cancer Surveillance and Public Health.International journal of environmental research and public health · 2022Review
- Risk Factors for Childhood Leukemia: Radiation and Beyond.Frontiers in public health · 2021Review
- Clustering of non-leukemia childhood cancer in Colombia: a nationwide study.F1000Research · 2021Article
- Article
- Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006-2014: a mixed ecological study.Epidemiology and health · 2020Article
- Spatial and temporal variations of childhood cancers: Literature review and contribution of the French national registry.Cancer medicine · 2018Review
- Background gamma radiation and childhood cancer in Germany: an ecological study.Radiation and environmental biophysics · 2017Article
- Spatial clustering of childhood acute lymphoblastic leukaemia in hungary.Pathology oncology research : POR · 2013Article
- Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology.Chemico-biological interactions · 2012Article
- A review of spatial methods in epidemiology, 2000-2010.Annual review of public health · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukemia is the most frequent malignancy in children under the age of 15 years. The question of whether childhood leukemia has a tendency for clustering or forms clusters has been studied for several decades. The environmental risk factor discussed most often is infection, which might result in spatial clustering and space-time clusters. The German Childhood Cancer Registry provided data on 11,946 children with leukemia diagnosed during 1987-2007, as classified in the International Classification for Childhood Cancer (third edition), aggregated by municipality. We used the Potthoff-Whittinghill model to test for a general trend for clustering and the spatial scan statistic to search for localized clusters. No evidence of global clustering was found, neither for the whole study population nor in sub-groups by age, period or population density, or for different types of leukemia. A similar result was found for localized clusters. The analysis shows no evidence of a tendency to clustering, however, aggregation of data at the municipality level might have diluted small localized clusters. The results of this study do not provide support for the hypothesis of an infectious or a spatial environmental etiology of childhood leukemia.
Indexed as
Identifiers
20623321What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.