Evidence map›Paper›PMID 20623305›Full record

Trial reportDysphagia2011

A randomized preventive rehabilitation trial in advanced head and neck cancer patients treated with chemoradiotherapy: feasibility, compliance, and short-term effects.

Lisette van der Molen, Maya A van Rossum, Lori M Burkhead, Ludi E Smeele, Coen R N Rasch, Frans J M Hilgers

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Dysphagia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01937793 nacompletednot on this mapstarted 2013, after this paper: background citation

Swallowing Exercises for Patients With Nasopharyngeal Cancer After Radiation Therapy

TypeinterventionalSponsorNational Taiwan University HospitalRan2013 to 2013Enrolled16ConditionsNasopharyngeal Cancer, DysphagiaArmseffortful swallowing exercise, Mendelsohn swallowing exercise
NCT03206242 completednot on this mapstarted 2015, after this paper: background citation

Rehabilitation Outcomes in Head and Neck Survivors

TypeobservationalSponsorChang Gung Memorial HospitalRan2015 to 2016Enrolled65ConditionsHead and Neck Cancer, Oral CancerArmsPhysiotherapy
NCT03545100 nacompletednot on this mapstarted 2018, after this paper: background citation

Rehabilitation Outcomes of Shoulder Function in Oral Cancer Survivors Cancer Survivors

TypeinterventionalSponsorChang Gung Memorial HospitalRan2018 to 2020Enrolled60ConditionsOral CancerArmsmotor control therapy, regular physical therapy
NCT04476004 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Electromyographic Visual Feedback for Spinal Accessory Nerve Dysfunction in Oral Cancer Survivors With Neck Dissection: a Randomized Clinical Trial

TypeinterventionalSponsorChang Gung Memorial HospitalRan2020 to 2021Enrolled24ConditionsOral CancerArmsscapular-focused exercise, visual feedback
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Guideline
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  3. Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
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  17. Randomised feasibility study to compare the use of TherabiteThe British journal of oral & maxillofacial surgery · 2018
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisette van der MolenDepartment of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Maya A van Rossum
Lori M Burkhead
Ludi E Smeele
Coen R N Rasch
Frans J M Hilgers

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess the effect of (preventive) rehabilitation on swallowing and mouth opening after concomitant chemoradiotherapy (CCRT). Forty-nine patients with advanced oral cavity, oropharynx, hypopharynx and larynx, or nasopharynx cancer treated with CCRT were randomized into a standard (S) or an experimental (E) preventive rehabilitation arm. Structured multidimensional assessment (i.e., videofluoroscopy, mouth-opening measurement, structured questionnaires) was performed before and 10 weeks after CCRT. In both S and E arms, feasibility was good (all patients could execute the exercises within a week) and compliance was satisfactory (mean days practiced per week was 4). Nevertheless, mouth opening, oral intake, and weight decreased significantly. Compared to similar CCRT studies at our institute, however, fewer patients were still tube-dependent after CCRT. Furthermore, some functional outcomes seemed less affected than those of studies in the literature that did not incorporate rehabilitation exercises. Patients in the E arm practiced significantly fewer days in total and per week, but they obtained results comparable to the S arm patients. Preventive rehabilitation (regardless of the approach, i.e., experimental or standard) in head and neck cancer patients, despite advanced stage and burdensome treatment, is feasible, and compared with historical controls, it seems helpful in reducing the extent and/or severity of various functional short-term effects of CCRT.

Indexed as

AdultAgedAntineoplastic AgentsCarcinoma, Squamous CellDeglutitionDeglutition DisordersDisease ProgressionExercise TherapyFeasibility StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMuscle Stretching ExercisesPain MeasurementAntineoplastic Agents

Identifiers

PMID20623305
PMCPMC3098976

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.