ArticleInternational journal of legal medicine2011
Morphological identification of right ventricular failure in cases of fatal pulmonary thromboembolism.
Article in International journal of legal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia.Scientific reports · 2024Article
- Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia.Scientific reports · 2021Article
- Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers.International journal of legal medicine · 2018Review
- Early markers of myocardial ischemia: from the experimental model to forensic pathology cases of sudden cardiac death.International journal of legal medicine · 2018Observational
- Granulomatosis with polyangiitis (Wegener's granulomatosis): a rare variant of sudden natural death.International journal of legal medicine · 2018Article
- Early markers for myocardial ischemia and sudden cardiac death.International journal of legal medicine · 2016Article
- Different degrees of ischaemic injury in the right and left ventricle in cases of severe, nonfatal, pulmonary embolism.International journal of legal medicine · 2015Article
- The risk of misinterpreting genital signs of sexual abuse in cadavers: a case report.International journal of legal medicine · 2013Article
- Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination.International journal of legal medicine · 2011Article
- Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of fatal ethanol intoxication.International journal of legal medicine · 2011Article
- Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning.International journal of legal medicine · 2011Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary thromboembolism is a life-threatening event potentially determining right ventricular failure. Even if the pathophysiology of this phenomenon has been widely investigated, no morphological demonstration of right ventricular ischemic damage determining right ventricular failure in cases of fatal pulmonary embolism has been reported till now. We performed an immunohistochemical investigation with the markers fibronectin and C5b-9 in 26 cases of fatal pulmonary thromboembolism (16 ♀, 10 ♂, mean age 56.4 years), as well as in 25 cases of myocardial infarction (16♀, 9♂, mean age 60.8 years) and 20 cases of hanging (3♀, 17♂, mean age 40.8 years). In each case, at least one tissue slide from both cardiac ventricles (free wall of the right ventricle, anterior and/or posterior wall of the left ventricle) was prepared. The reactions were semiquantitatively classified and the groups compared. In the study group, the occurrence of ischemic changes at the right ventricle was significantly higher than in cases of myocardial infarction and global hypoxia due to hanging. The determining aspect of the immunohistochemical examination is the identification of the prevalent ischemic lesion at the right ventricle compared to the left one. This may indicate the primary involvement of the right ventricle thus demonstrating a right ventricular failure.
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