ReviewSeminars in immunopathology2010
Cell-autonomous and environmental contributions to the interstitial migration of T cells.
Review in Seminars in immunopathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images.Journal of translational medicine · 2025Article
- Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.Nature communications · 2024Article
- Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition.Journal for immunotherapy of cancer · 2023Article
- Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer.eLife · 2022Article
- Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.PLoS computational biology · 2022Article
- APE1 may influence CD4+ naïve T cells on recurrence free survival in early stage NSCLC.BMC cancer · 2021Article
- γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.Immunological reviews · 2020Review
- Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo.eLife · 2020Article
- From stem cell to immune effector: how adhesion, migration, and polarity shape T-cell and natural killer cell lymphocyte development in vitro and in vivo.Molecular biology of the cell · 2020Review
- Tumor progression mechanisms: Insights from the central immune regulation of tissue homeostasis.Oncology letters · 2019Review
- T cell migration in microchannels densely packed with T cells.Scientific reports · 2019Article
- The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment.Frontiers in immunology · 2019Review
- The consequence of matrix dysfunction on lung immunity and the microbiome in COPD.European respiratory review : an official journal of the European Respiratory Society · 2018Article
- Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas.Frontiers in immunology · 2018Article
- T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.eLife · 2017Article
- Intermittent CaeLife · 2017Article
- ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.Nature communications · 2017Article
- Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation.Scientific reports · 2017Article
- High-dose wogonin exacerbates DSS-induced colitis by up-regulating effector T cell function and inhibiting Treg cell.Journal of cellular and molecular medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key to understanding the functioning of the immune system is to define the mechanisms that facilitate directed lymphocyte migration to and within tissues. The recent development of improved imaging technologies, most prominently multi-photon microscopy, has enabled the dynamic visualization of immune cells in real-time directly within intact tissues. Intravital imaging approaches have revealed high spontaneous migratory activity of T cells in secondary lymphoid organs and inflamed tissues. Experimental evidence points towards both environmental and cell-intrinsic cues involved in the regulation of lymphocyte motility in the interstitial space. Based on these data, several conceptually distinct models have been proposed in order to explain the coordination of lymphocyte migration both at the single cell and population level. These range from "stochastic" models, where chance is the major driving force, to "deterministic" models, where the architecture of the microenvironment dictates the migratory trajectory of cells. In this review, we focus on recent advances in understanding naïve and effector T cell migration in vivo. In addition, we discuss some of the contradictory experimental findings in the context of theoretical models of migrating leukocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.