ArticlePsychopharmacology2011
Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-analysis of molecular imaging of serotonin transporters in major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Pooled it
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.Nutrients · 2025Trial
- Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Neural correlates differ between crystallized and fluid intelligence in adolescents.Translational psychiatry · 2025Article
- Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.The international journal of neuropsychopharmacology · 2023Article
- Brain gain-Is the cognitive performance of domestic hens affected by a functional polymorphism in the serotonin transporter gene?Frontiers in psychology · 2022Article
- Impact of Long-Rope Jumping on Monoamine and Attention in Young Adults.Brain sciences · 2021Article
- Long acting aripiprazole influences cognitive functions in recent onset schizophrenia.Psychopharmacology · 2021Article
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- Alterations in serotonin transporter and body image-related cognition in anorexia nervosa.NeuroImage. Clinical · 2019Article
- Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies.Frontiers in psychiatry · 2018Review
- Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET.Human brain mapping · 2017Article
- Correlating Gray Matter Volume with Individual Difference in the Flanker Interference Effect.PloS one · 2015Article
- Response inhibition and interference control in obsessive-compulsive spectrum disorders.Frontiers in human neuroscience · 2014Review
- Article
- The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans.Human brain mapping · 2013Article
- Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation.The journal of physiological sciences : JPS · 2013Article
- Article
- Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory.Journal of cognitive neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) protein is a key regulator in the serotonin system. We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions.
methodsThirty-two healthy subjects (25 males, mean age 26.0 years, range 19-37) underwent positron emission tomography using the SERT ligand [(11)C]DASB. Subjects underwent the following tests: Stroop Color Word Test, Trail Making Test B, Rey's Auditory Verbal Learning Test and Complex Figure Test, logical reasoning subtest from Intelligenz-Struktur-Test 2000 R, and a Danish version of National Adult Reading Test.
resultsWe found positive associations between performance on the Stroop Color Word Test and right-sided dorsolateral prefrontal SERT binding (R(2) = 0.12, p = 0.048). Furthermore, scores of logical reasoning (correlating with IQ) and educational level associated positively with SERT binding in the caudate, most prominent on the left side (logical reasoning: R(2) = 0.34, p = 0.0026 (left), R(2) = 0.2, p = 0.022 (right), educational level: R(2) = 0.19, p = 0.012 (left), R(2) = 0.15, p = 0.027 (right)). Scores of logical reasoning also associated with left-sided ventrolateral prefrontal cortex (R(2) = 0.24, p = 0.014). There were no significant associations between SERT binding and tests of long-term episodic memory.
conclusionsThe results imply that in healthy subjects, high SERT binding in fronto-striatal regions is associated with better performance on tasks involving executive function and logical reasoning.
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Registered trials
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