ArticleNature methods2010
Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors.
Article in Nature methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Pooled it
- Lossless Altered Histone Modification Analysis System (LAHMAS).Lab on a chip · 2025Article
- H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos.Nature cell biology · 2025Article
- ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements.Nature genetics · 2024Article
- Single-Cell RNA Sequencing and Combinatorial Approaches for Understanding Heart Biology and Disease.Biology · 2024Review
- Cell-free chromatin immunoprecipitation can determine tumor gene expression in lung cancer patients.Molecular oncology · 2023Article
- Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability.Nature cell biology · 2022Article
- Profiling Chromatin Accessibility at Single-cell Resolution.Genomics, proteomics & bioinformatics · 2021Review
- ChIP-Seq from Limited Starting Material of K562 Cells andBio-protocol · 2020Article
- aFARP-ChIP-seq, a convenient and reliable method for genome profiling in as few as 100 cells with a capability for multiplexing ChIP-seq.Epigenetics · 2019Article
- Understanding histone H3 lysine 36 methylation and its deregulation in disease.Cellular and molecular life sciences : CMLS · 2019Review
- TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay.Life science alliance · 2019Article
- Cell Specificity of Human Regulatory Annotations and Their Genetic Effects on Gene Expression.Genetics · 2019Article
- High-throughput ChIPmentation: freely scalable, single day ChIPseq data generation from very low cell-numbers.BMC genomics · 2019Article
- Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP.PloS one · 2019Article
- Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer.Genome biology · 2018Article
- Microfluidic Low-Input Fluidized-Bed Enabled ChIP-seq Device for Automated and Parallel Analysis of Histone Modifications.Analytical chemistry · 2018Article
- Capturing the 'ome': the expanding molecular toolbox for RNA and DNA library construction.Nucleic acids research · 2018Review
- Low-input and multiplexed microfluidic assay reveals epigenomic variation across cerebellum and prefrontal cortex.Science advances · 2018Article
- Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells.BMC developmental biology · 2018Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Current methods for whole-genome mapping of protein-DNA interactions, performed by coupling chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq), require large amounts of starting materials, which precludes their application to rare cell types. Here we combine a high-sensitivity ChIP assay with a new library preparation procedure to map histone modifications in as few as 10,000 cells. We used the technique to characterize mouse hematopoietic progenitors and thereby gain insight into their developmental program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.